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Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 1933

Mitogen-activated protein kinase 14 [G110A](Mouse)
Merck Research Laboratories

BDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)

IC50: 0.100nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14(Mouse)
Merck Research Laboratories

BDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)

IC50: 0.130nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110D](Mouse)
Merck Research Laboratories

BDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)

IC50: 0.140nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14(Mouse)
Merck Research Laboratories

BDBM15242(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(4...)

IC50: 0.740nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14(Mouse)
Merck Research Laboratories

BDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)

IC50: 0.800nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14(Mouse)
Merck Research Laboratories

BDBM15241(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)

IC50: 3.20nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14(Mouse)
Merck Research Laboratories

BDBM15243(1-(2,6-dichlorophenyl)-6-[(2,4-difluorophenyl)sulf...)

IC50: 4.30nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110A](Mouse)
Merck Research Laboratories

BDBM15242(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(4...)

IC50: 6.40nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110D](Mouse)
Merck Research Laboratories

BDBM15242(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(4...)

IC50: 14nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110A](Mouse)
Merck Research Laboratories

BDBM15241(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)

IC50: 26nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110A](Mouse)
Merck Research Laboratories

BDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)

IC50: 34nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110A](Mouse)
Merck Research Laboratories

BDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)

IC50: 37nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110D](Mouse)
Merck Research Laboratories

BDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)

IC50: 56nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110A](Mouse)
Merck Research Laboratories

BDBM15243(1-(2,6-dichlorophenyl)-6-[(2,4-difluorophenyl)sulf...)

IC50: 61nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110D](Mouse)
Merck Research Laboratories

BDBM15241(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)

IC50: 67nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14(Mouse)
Merck Research Laboratories

BDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)

IC50: 75nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110D](Mouse)
Merck Research Laboratories

BDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)

IC50: 120nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 14 [G110D](Mouse)
Merck Research Laboratories

BDBM15243(1-(2,6-dichlorophenyl)-6-[(2,4-difluorophenyl)sulf...)

IC50: 160nMpH: 7.0 T: 30°CAssay Description:The biochemical activity of compounds was determined by incubation with wild-type or mutant p38alpha enzymes, and substrates in the presence ATP/[gam...More data for this Ligand-Target Pair

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3D Structure (crystal)