Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50000244
TargetMuscarinic acetylcholine receptor M1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003355(5-(4-Hexylsulfanyl-[1,2,5]thiadiazol-3-yl)-1-methy...)
Affinity DataIC50:  0.00100nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003363(1-Methyl-5-(4-pentylsulfanyl-[1,2,5]thiadiazol-3-y...)
Affinity DataIC50:  0.00200nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003366(1-Methyl-5-(4-pentyloxy-[1,2,5]thiadiazol-3-yl)-1,...)
Affinity DataIC50:  0.00400nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003359(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)
Affinity DataIC50:  0.00800nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003351(3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003369(1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,...)
Affinity DataIC50:  1.60nMAssay Description:In vitro binding affinity against rat hippocampus Muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003363(1-Methyl-5-(4-pentylsulfanyl-[1,2,5]thiadiazol-3-y...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003351(3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,...)
Affinity DataIC50:  3nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003366(1-Methyl-5-(4-pentyloxy-[1,2,5]thiadiazol-3-yl)-1,...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003366(1-Methyl-5-(4-pentyloxy-[1,2,5]thiadiazol-3-yl)-1,...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003363(1-Methyl-5-(4-pentylsulfanyl-[1,2,5]thiadiazol-3-y...)
Affinity DataIC50:  4.80nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003351(3-(4-butoxy-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003355(5-(4-Hexylsulfanyl-[1,2,5]thiadiazol-3-yl)-1-methy...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003365(3-(3-(ethoxy)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetra...)
Affinity DataIC50:  5.70nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003356(5-(4-Heptyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,...)
Affinity DataIC50:  6.20nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003355(5-(4-Hexylsulfanyl-[1,2,5]thiadiazol-3-yl)-1-methy...)
Affinity DataIC50:  6.5nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003359(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003356(5-(4-Heptyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,...)
Affinity DataIC50:  9nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003359(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)
Affinity DataIC50:  9.70nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003362(2-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-3-pen...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003358(5-(4-Chloro-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003356(5-(4-Heptyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003362(2-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-3-pen...)
Affinity DataIC50:  13nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003354(2-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-3-pen...)
Affinity DataIC50:  16nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003357(2-Butoxy-3-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-...)
Affinity DataIC50:  17nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003357(2-Butoxy-3-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-...)
Affinity DataIC50:  17nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003364(2-Hexyloxy-3-(1-methyl-1,2,5,6-tetrahydro-pyridin-...)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003349(2-Heptyloxy-3-(1-methyl-1,2,5,6-tetrahydro-pyridin...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003369(1-Methyl-5-(4-propoxy-[1,2,5]thiadiazol-3-yl)-1,2,...)
Affinity DataIC50:  18nMAssay Description:In vitro binding affinity against rat hippocampus Muscarinic acetylcholine receptor M1 using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003354(2-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-3-pen...)
Affinity DataIC50:  19nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003364(2-Hexyloxy-3-(1-methyl-1,2,5,6-tetrahydro-pyridin-...)
Affinity DataIC50:  20nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003361(5-(4-Methoxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003349(2-Heptyloxy-3-(1-methyl-1,2,5,6-tetrahydro-pyridin...)
Affinity DataIC50:  27nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003352(2-Hexylsulfanyl-3-(1-methyl-1,2,5,6-tetrahydro-pyr...)
Affinity DataIC50:  28nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003352(2-Hexylsulfanyl-3-(1-methyl-1,2,5,6-tetrahydro-pyr...)
Affinity DataIC50:  44nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003365(3-(3-(ethoxy)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetra...)
Affinity DataIC50:  48nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003360(2-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-3-pro...)
Affinity DataIC50:  58nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003360(2-(1-Methyl-1,2,5,6-tetrahydro-pyridin-3-yl)-3-pro...)
Affinity DataIC50:  65nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003350(5-(4-Heptyl-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...)
Affinity DataIC50:  73nMAssay Description:Displacement of [3H]-pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM46858(1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid...)
Affinity DataIC50:  77nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003371(5-(4-Hexyloxy-furazan-3-yl)-1-methyl-1,2,3,6-tetra...)
Affinity DataIC50:  84nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003372(CHEMBL308168 | Hexyl-[4-(1-methyl-1,2,5,6-tetrahyd...)
Affinity DataIC50:  105nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003372(CHEMBL308168 | Hexyl-[4-(1-methyl-1,2,5,6-tetrahyd...)
Affinity DataIC50:  105nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003361(5-(4-Methoxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,...)
Affinity DataIC50:  148nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003367(2-Ethoxy-3-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-...)
Affinity DataIC50:  175nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003350(5-(4-Heptyl-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...)
Affinity DataIC50:  187nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003367(2-Ethoxy-3-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-...)
Affinity DataIC50:  200nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-oxotremorine-M (Oxo-M) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003350(5-(4-Heptyl-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2,3...)
Affinity DataIC50:  224nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003353(2-Chloro-3-(1-methyl-1,2,5,6-tetrahydro-pyridin-3-...)
Affinity DataIC50:  276nMAssay Description:In vitro binding affinity against rat hippocampus M1 receptor using [3H]-pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMuscarinic acetylcholine receptor M1(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50003371(5-(4-Hexyloxy-furazan-3-yl)-1-methyl-1,2,3,6-tetra...)
Affinity DataIC50:  277nMAssay Description:Displacement of [3H]-oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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