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Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50013737
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134148((5R,6R)-6-Benzo[1,3]dioxol-5-yl-2-butyl-2,3,6,7,12...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134148((5R,6R)-6-Benzo[1,3]dioxol-5-yl-2-butyl-2,3,6,7,12...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134125((5R,6R)-6-Benzo[1,3]dioxol-5-yl-2-benzyl-2,3,6,7,1...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134143((5R,6R)-6-Benzo[1,3]dioxol-5-yl-2-cyclohexyl-2,3,6...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134124((6R,12aR)-2-Butyl-6-(4-methoxy-phenyl)-2,3,6,7,12,...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134123((6R,7R)-10-Butyl-6-(4-methoxy-phenyl)-5,6,9,10,11a...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134128((5R,6R)-6-Benzo[1,3]dioxol-5-yl-2-isopropyl-2,3,6,...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134128((5R,6R)-6-Benzo[1,3]dioxol-5-yl-2-isopropyl-2,3,6,...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134145((R)-10-Benzo[1,3]dioxol-5-yl-2-benzyl-3a,4,9,10-te...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134135((5R,6R)-2-Cyclopropylmethyl-6-(4-methoxy-phenyl)-2...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  6nMAssay Description:Inhibition of bovine aorta PDE5 (Phosphodiesterse 5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134123((6R,7R)-10-Butyl-6-(4-methoxy-phenyl)-5,6,9,10,11a...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134132((5R,6R)-2-Ethyl-6-(4-methoxy-phenyl)-2,3,6,7,12,12...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134136((R)-10-(4-Methoxy-phenyl)-2-methyl-3a,4,9,10-tetra...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134133((5R,6R)-6-Benzo[1,3]dioxol-5-yl-2,3,6,7,12,12a-hex...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134133((5R,6R)-6-Benzo[1,3]dioxol-5-yl-2,3,6,7,12,12a-hex...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134138((R)-2-Butyl-6-(4-chloro-phenyl)-2,3,6,7,12,12a-hex...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134126((5R,6R)-2-Cyclopropyl-6-(4-methoxy-phenyl)-2,3,6,7...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134142((R)-2-Benzyl-10-(4-methoxy-phenyl)-3a,4,9,10-tetra...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134137((5R,6R)-2-Cyclopropylmethyl-6-p-tolyl-2,3,6,7,12,1...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134139((R)-2-Butyl-6-p-tolyl-2,3,6,7,12,12a-hexahydro-pyr...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134140((5R,6R)-6-(4-Methoxy-phenyl)-2-methyl-2,3,6,7,12,1...)
Affinity DataIC50:  41nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134131((3aR,10S)-2-Benzyl-10-(4-methoxy-phenyl)-1,2,3a,4,...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134122((3aR,10R)-10-Benzo[1,3]dioxol-5-yl-2-methyl-2,3,3a...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134146((R)-2-Butyl-6-(4-methoxy-phenyl)-2,3,6,7,12,12a-he...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  74nMAssay Description:Inhibition of bovine retina PDE6 (Phosphodiesterase 6)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134149((5S,6R)-6-Benzo[1,3]dioxol-5-yl-2-methyl-2,3,6,7,1...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134129((R)-2-Butyl-6-phenyl-2,3,6,7,12,12a-hexahydro-pyra...)
Affinity DataIC50:  91nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50409731(CHEMBL2111963)
Affinity DataIC50:  138nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134141(4-((R)-2-Butyl-1,4-dioxo-1,2,3,4,6,7,12,12a-octahy...)
Affinity DataIC50:  758nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of bovine aorta PDE1 (Phosphodiesterase 1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetP04972/P11541/P16586/P22571/P23439/Q95142(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of bovine retina PDE6 (Phosphodiesterase 6)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134147((5R,6S)-6-Benzo[1,3]dioxol-5-yl-2-methyl-2,3,6,7,1...)
Affinity DataIC50:  6.00E+3nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of human recombinant PDE4 (Phosphodiesterase 4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPhosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of bovine aorta PDE3 (Phosphodiesterase 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of bovine aorta PDE1 (Phosphodiesterase 1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPhosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of bovine aorta PDE3 (Phosphodiesterase 3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134144((3aR,10R)-2-Butyl-10-(4-methoxy-phenyl)-2,3,3a,4,9...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Human recombinant PDE4 (Phosphodiesterase 4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bovine)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134134((5S,6S)-6-Benzo[1,3]dioxol-5-yl-2-methyl-2,3,6,7,1...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against bovine phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Human recombinant PDE2 (Phosphodiesterase 2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Human recombinant PDE2 (Phosphodiesterase 2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed