Compile Data Set for Download or QSAR
maximum 50k data
Found 60 Enz. Inhib. hit(s) with all data for entry = 50013844
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135404(2-(Cyclopropanecarbonyl-amino)-thiazole-5-carboxyl...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13242(2-[(butylcarbamoyl)amino]-4-methyl-N-(2,4,6-trimet...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Lck kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  44nMAssay Description:Inhibition of Jak3 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13242(2-[(butylcarbamoyl)amino]-4-methyl-N-(2,4,6-trimet...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  71nMAssay Description:Inhibition of Fyn kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13240(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13240(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Affinity DataIC50:  240nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  310nMAssay Description:Inhibition of Hck kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13224(2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...)
Affinity DataIC50:  320nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13232(2-(2-furoylamino)-N-mesityl-4-methyl-1,3-thiazole-...)
Affinity DataIC50:  360nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13245(2-[(butylcarbamoyl)amino]-N-(2-chloro-6-methylphen...)
Affinity DataIC50:  620nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13222(2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13237(5-N-(2-chloro-6-methylphenyl)-2-N-(furan-2-)-4-met...)
Affinity DataIC50:  710nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13222(2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...)
Affinity DataIC50:  720nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13224(2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  880nMAssay Description:Inhibition of CD3/CD28 T-cell proliferation assay in PBL (peripheral blood lymphocytes)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13250(2-N-benzene-5-N-(2-chloro-6-methylphenyl)-1,3-thia...)
Affinity DataIC50:  890nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13220(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13239(2-[[(Cyclopropyl)carbonyl]-amino]-4-methyl-N-(2-ch...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13217(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13220(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13217(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13253(5-N-(2-chloro-6-methylphenyl)-2-N-(furan-2-)-1,3-t...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13219(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13238(2-N-benzene-5-N-(2-chloro-6-methylphenyl)-4-methyl...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13215(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13215(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13219(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13218(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity of the compound against HER1 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13221(BMS-354825 tert-Butoxycarbamate Analog 5e | CHEMBL...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13228(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Affinity DataIC50:  2.43E+4nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1/2/3/4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of FGF receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of KDR kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of FAK kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CDK2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13246(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of HER2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13218(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135402(CHEMBL130971 | [4-Ethyl-5-(2,4,6-trimethyl-phenylc...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135397(CHEMBL340773 | [4-Phenyl-5-(2,4,6-trimethyl-phenyl...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135407(CHEMBL128581 | [4-Trifluoromethyl-5-(2,4,6-trimeth...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135403(CHEMBL130320 | [5-(2,4,6-Trimethyl-phenylcarbamoyl...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibitory activity of the compound human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13227(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Affinity DataIC50:  4.03E+4nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13226(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Affinity DataIC50:  4.57E+4nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135396(CHEMBL336544 | [5-(2,4-Dichloro-phenylcarbamoyl)-4...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50135406(CHEMBL131167 | [5-(1,2-Dimethyl-propylcarbamoyl)-4...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibition of murine Lck kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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