Compile Data Set for Download or QSAR
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Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50013993
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049736(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50067424((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)
Affinity DataKi:  0.450nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25877(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)
Affinity DataKi:  0.490nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)
Affinity DataKi:  2.60nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049735(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  2.61nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)
Affinity DataKi:  3.80nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049738(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049736(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Affinity DataKi:  5.10nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA A receptor alpha-4/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049735(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  7.80nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25879(3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)
Affinity DataKi:  15nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25877(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)
Affinity DataKi:  21.4nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049736(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Affinity DataKi:  26.3nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049736(8-Ethynyl-5-methyl-6-oxo-5,6-dihydro-4H-2,5,10b-tr...)
Affinity DataKi:  26.9nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50067424((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)
Affinity DataKi:  27.4nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25877(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)
Affinity DataKi:  28.4nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25877(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)
Affinity DataKi:  28.8nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM26267(RO-154513 | Ro15-4513 | [3H]Ro15-4513 | ethyl 12-a...)
Affinity DataKi:  33nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50067424((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)
Affinity DataKi:  48.5nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA A receptor alpha-4/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25877(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)
Affinity DataKi:  53nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049735(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  58.6nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50067424((S)-9-Methoxy-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11...)
Affinity DataKi:  83nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049738(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  114nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049738(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  121nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049738(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  142nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049735(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  143nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA A receptor alpha-4/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049738(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  159nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50049735(5-Methyl-6-oxo-8-trimethylsilanylethynyl-5,6-dihyd...)
Affinity DataKi:  197nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25879(3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25879(3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha1-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGABA A receptor alpha-4/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25879(3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)
Affinity DataKi:  1.55E+3nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25879(3-({12-ethynyl-8-methyl-9-oxo-2,4,8-triazatricyclo...)
Affinity DataKi: >2.00E+3nMAssay Description:In vitro binding affinity for human GABA-A receptor alpha6-beta3-gamma2 subunits expressed in L(tk-) cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed