Compile Data Set for Download or QSAR
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Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50000291
TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004071((S)-2-Phenylmethanesulfonylamino-3-[4-(4-piperidin...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004061((S)-2-Hexanoylamino-3-[4-(4-piperidin-4-yl-butoxy)...)
Affinity DataIC50:  35nMAssay Description:Inhibition of HUVEC attachment to human vitronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004060((S)-2-Benzyloxycarbonylamino-3-[4-(4-piperidin-4-y...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004065((S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-(butane-1-su...)
Affinity DataIC50:  780nMAssay Description:Inhibition of HUVEC attachment to human fibronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004066((S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-phenylmethan...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004062((S)-3-[4-(7-Amino-heptyloxy)-phenyl]-2-benzyloxyca...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of HUVEC attachment to human fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004064((S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-hexanoylamin...)
Affinity DataIC50:  3.80E+3nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004067((S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-(3-phenyl-pr...)
Affinity DataIC50:  8.00E+3nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004059((S)-2-Benzyloxycarbonylamino-3-[4-(3-tert-butylami...)
Affinity DataIC50:  2.20E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004070((S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-benzyloxycar...)
Affinity DataIC50:  2.60E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50241180((6S,12S,15S)-1,6-diamino-12-(carboxymethyl)-16-hyd...)
Affinity DataIC50:  2.60E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004072((S)-2-Benzyloxycarbonylamino-3-[4-(3-tert-butylami...)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004069((S)-2-Amino-3-[4-(6-amino-hexyloxy)-phenyl]-propio...)
Affinity DataIC50:  3.50E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004063((S)-3-[4-(5-Amino-pentyloxy)-phenyl]-2-benzyloxyca...)
Affinity DataIC50:  3.60E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004056((S)-3-[4-(8-Amino-octyloxy)-phenyl]-2-benzyloxycar...)
Affinity DataIC50:  4.00E+4nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004057(3-[4-(6-Amino-hexyloxy)-phenyl]-propionic acid | C...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [125I]-Fibrinogen binding to fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-V/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Affinity DataIC50:  1.00E+5nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIntegrin alpha-V/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Affinity DataIC50:  2.60E+5nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetIntegrin alpha-5/beta-1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Affinity DataIC50: >3.00E+5nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIntegrin alpha-IIb/beta-3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004068((S)-2-Benzyloxycarbonylamino-3-[4-(3-phenyl-propox...)
Affinity DataIC50: >1.00E+6nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed