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Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 718
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5332(3-{5-[2-(piperidin-1-yl)ethoxy]-1H-indol-2-yl}-1,2...)
Affinity DataIC50:  4nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5330(3-{5-[2-(4-acetylpiperazin-1-yl)ethoxy]-1H-indol-2...)
Affinity DataIC50:  4nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5333(3-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-indol-2...)
Affinity DataIC50:  5nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5335(3-{5-[(3-aminopyrrolidin-1-yl)carbonyl]-1H-indol-2...)
Affinity DataIC50:  5nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5334(3-[5-(piperazin-1-ylcarbonyl)-1H-indol-2-yl]-1,2-d...)
Affinity DataIC50:  5nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5336(2-(2-oxo-1,2-dihydroquinolin-3-yl)-N-(pyrrolidin-3...)
Affinity DataIC50:  6nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5280(5-phenyl-N-(pyridin-2-yl)-1,3-thiazol-2-amine | N-...)
Affinity DataIC50:  7nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5329(3-(5-{2-[(2-methoxyethyl)(methyl)amino]ethoxy}-1H-...)
Affinity DataIC50:  7nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5331(1-(3-{[2-(2-oxo-1,2-dihydroquinolin-3-yl)-1H-indol...)
Affinity DataIC50:  8nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5337(3-{5-[(4-methylpiperazine-1-)sulfonyl]-1H-indol-2-...)
Affinity DataIC50:  10nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5338(3-[5-(piperazine-1-sulfonyl)-1H-indol-2-yl]-1,2-di...)
Affinity DataIC50:  11nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5340(2-(2-oxo-1,2-dihydroquinolin-3-yl)-N-(pyrrolidin-3...)
Affinity DataIC50:  14nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5339(3-{5-[(3-aminopyrrolidine-1-)sulfonyl]-1H-indol-2-...)
Affinity DataIC50:  16nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5344(5-phenyl-N-(pyrazin-2-yl)-1,3-thiazol-2-amine | am...)
Affinity DataIC50:  23nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5345(5-phenyl-N-(pyrimidin-4-yl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  36nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5342(N-(5-phenyl-1,3-thiazol-2-yl)benzamide | aminothia...)
Affinity DataIC50:  81nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5346(5-phenyl-N-(pyrimidin-2-yl)-1,3-thiazol-2-amine | ...)
Affinity DataIC50:  137nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5341(N-butyl-N,3-dimethyl-4-[(E)-2-(5-nitro-1,3-thiazol...)
Affinity DataIC50:  151nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5347(5-phenyl-N-(pyridin-3-yl)-1,3-thiazol-2-amine | am...)
Affinity DataIC50:  240nMpH: 7.4 T: 22°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed