Compile Data Set for Download or QSAR
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Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50000321
TargetLanosterol 14-alpha demethylase(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  47nMAssay Description:Inhibition of Progesterone 21-hydroxylase cytochrome P450 21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLanosterol 14-alpha demethylase(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  119nMAssay Description:Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 11B1, mitochondrial(Bovine)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  135nMAssay Description:Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 11B1, mitochondrial(Bovine)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  152nMAssay Description:Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 7A1(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  195nMAssay Description:Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 11B1, mitochondrial(Bovine)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  247nMAssay Description:Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2A2(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  369nMAssay Description:Inhibition of cytochrome P450 progesterone 15-alpha hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2A2(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  543nMAssay Description:Inhibition of cholesterol side chain cleavage cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 7A1(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  546nMAssay Description:Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  570nMAssay Description:Inhibition of progesterone 6-beta-hydroxylase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 11B1, mitochondrial(Bovine)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  608nMAssay Description:Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2A2(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  728nMAssay Description:Inhibition of cytochrome P450 progesterone 15-alpha hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  786nMAssay Description:Inhibition of Corticoid 11-beta-hydroxylase cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCytochrome P450 3A4(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  897nMAssay Description:Inhibition of progesterone 6-beta-hydroxylase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2A2(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of cytochrome P450 progesterone 15-alpha hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of cholesterol side chain cleavage cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 7A1(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of cytochrome P450 Cholesterol 7-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of progesterone 6-beta-hydroxylase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetLanosterol 14-alpha demethylase(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetLanosterol 14-alpha demethylase(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 7A1(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of lanosterol 14 alpha-demethylase cytochrome P450 51AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  2.95E+3nMAssay Description:Inhibition of cholesterol side chain cleavage cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  3.92E+3nMAssay Description:Inhibition of cholesterol side chain cleavage cytochrome P450More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAromatase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of cytochrome P450 19A1 involved in steroid biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSteroid 21-hydroxylase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  4.46E+3nMAssay Description:Inhibition of Progesterone 21-hydroxylase cytochrome P450 21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of cytochrome P450 19A1 involved in steroid biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSteroid 21-hydroxylase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  6.57E+3nMAssay Description:Inhibition of Progesterone 21-hydroxylase cytochrome P450 21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSteroid 21-hydroxylase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  9.01E+3nMAssay Description:Inhibition of Progesterone 21-hydroxylase cytochrome P450 21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSteroid 21-hydroxylase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of cytochrome P450 progesterone 2-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C11(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  2.04E+4nMAssay Description:Inhibition of cytochrome P450 progesterone 2-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C11(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004442((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...)
Affinity DataIC50:  3.43E+4nMAssay Description:Inhibition of cytochrome P450 progesterone 2-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAromatase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50004441((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...)
Affinity DataIC50:  3.83E+4nMAssay Description:Inhibition of cytochrome P450 19A1 involved in steroid biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAromatase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  3.96E+4nMAssay Description:Inhibition of cytochrome P450 19A1 involved in steroid biosynthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C11(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  8.41E+4nMAssay Description:Inhibition of cytochrome P450 progesterone 15-alpha hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C11(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  1.04E+5nMAssay Description:Inhibition of cytochrome P450 progesterone 2-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAromatase(Human)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of progesterone 6-beta-hydroxylase in rat hepatic microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed