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Report error Found 47 Enz. Inhib. hit(s) with all data for entry = 50014408
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142315(2-[4-(Carboxy-difluoro-methyl)-benzyl]-2-[4-(diflu...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142307(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311(CHEMBL266056 | [(4-{2-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311(CHEMBL266056 | [(4-{2-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142316(2-(4-Acetylsulfamoyl-benzyl)-2-[4-(difluoro-phosph...)
Affinity DataIC50:  90nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142313(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142317((2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl)difluo...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142319(CHEMBL276376 | [(4-{2,2-Bis-benzyloxy-3-[4-(difluo...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142312(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142310(CHEMBL9087 | {[4-((E)-2-Benzoyl-2,5-diphenyl-pent-...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142318(CHEMBL428651 | {[2-Chloro-4-(3-oxo-2,3-diphenyl-pr...)
Affinity DataIC50:  360nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142308(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  390nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142307(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  540nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311(CHEMBL266056 | [(4-{2-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50:  580nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311(CHEMBL266056 | [(4-{2-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50:  580nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142309(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-oxo-...)
Affinity DataIC50:  800nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142321(2-[4-(Difluoro-phosphono-methyl)-benzyl]-2-(4-meth...)
Affinity DataIC50:  940nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142312(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142317((2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl)difluo...)
Affinity DataIC50:  1.22E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142319(CHEMBL276376 | [(4-{2,2-Bis-benzyloxy-3-[4-(difluo...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142313(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  1.65E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142316(2-(4-Acetylsulfamoyl-benzyl)-2-[4-(difluoro-phosph...)
Affinity DataIC50:  1.70E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142315(2-[4-(Carboxy-difluoro-methyl)-benzyl]-2-[4-(diflu...)
Affinity DataIC50:  1.90E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142310(CHEMBL9087 | {[4-((E)-2-Benzoyl-2,5-diphenyl-pent-...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142314(CHEMBL267022 | difluoro(4-(3-oxo-2,3-diphenylpropy...)
Affinity DataIC50:  2.00E+3nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142318(CHEMBL428651 | {[2-Chloro-4-(3-oxo-2,3-diphenyl-pr...)
Affinity DataIC50:  2.40E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142308(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  3.80E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142310(CHEMBL9087 | {[4-((E)-2-Benzoyl-2,5-diphenyl-pent-...)
Affinity DataIC50:  5.50E+3nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142309(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-oxo-...)
Affinity DataIC50:  6.63E+3nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142321(2-[4-(Difluoro-phosphono-methyl)-benzyl]-2-(4-meth...)
Affinity DataIC50:  7.20E+3nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142320(CHEMBL9047 | {Difluoro-[5-(3-oxo-2,3-diphenyl-prop...)
Affinity DataIC50:  1.60E+4nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142314(CHEMBL267022 | difluoro(4-(3-oxo-2,3-diphenylpropy...)
Affinity DataIC50:  1.60E+4nMAssay Description:In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142307(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50:  1.90E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142316(2-(4-Acetylsulfamoyl-benzyl)-2-[4-(difluoro-phosph...)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142318(CHEMBL428651 | {[2-Chloro-4-(3-oxo-2,3-diphenyl-pr...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311(CHEMBL266056 | [(4-{2-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) overexpressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142309(4-{2-[4-(Difluoro-phosphono-methyl)-benzyl]-3-oxo-...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142312(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142311(CHEMBL266056 | [(4-{2-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142314(CHEMBL267022 | difluoro(4-(3-oxo-2,3-diphenylpropy...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142319(CHEMBL276376 | [(4-{2,2-Bis-benzyloxy-3-[4-(difluo...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142315(2-[4-(Carboxy-difluoro-methyl)-benzyl]-2-[4-(diflu...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142317((2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl)difluo...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142320(CHEMBL9047 | {Difluoro-[5-(3-oxo-2,3-diphenyl-prop...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142321(2-[4-(Difluoro-phosphono-methyl)-benzyl]-2-(4-meth...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142308(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50142313(2,2-Bis-[4-(difluoro-phosphono-methyl)-benzyl]-mal...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed