Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50014678
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146058BDBM50146058(Benzo[de]isochromene-1,3-dione | CHEMBL316059)
Affinity DataIC50: 8.80E+3nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146048BDBM50146048(2,3-Dihydro-1H-naphtho[2,1-b]oxepin-4-one | CHEMBL...)
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146067BDBM50146067(1,2-Dihydro-benzo[f]thiochromen-3-one | CHEMBL3143...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146052BDBM50146052(5-Benzyloxy-1,2-dihydro-benzo[f]chromen-3-one | CH...)
Affinity DataIC50: 2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146063BDBM50146063(2-Isobutyl-1,2-dihydro-benzo[f]chromen-3-one | CHE...)
Affinity DataIC50: 2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146044BDBM50146044(2-Allyl-1,2-dihydro-benzo[f]chromen-3-one | CHEMBL...)
Affinity DataIC50: 2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146068BDBM50146068(7-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50: 3.90E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146062BDBM50146062(9-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50: 4.10E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146046BDBM50146046(1-Phenyl-1,2-dihydro-benzo[f]chromen-3-one | 1-phe...)
Affinity DataIC50: 4.30E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146069BDBM50146069(6-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50: 4.40E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146054BDBM50146054(2-Methyl-1,2-dihydro-benzo[f]chromen-3-one | CHEMB...)
Affinity DataIC50: 5.20E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146060BDBM50146060(1H-Naphtho[2,1-b]furan-2-one | CHEMBL314020)
Affinity DataIC50: 5.90E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146047BDBM50146047(3,4-Dihydro-benzo[h]chromen-2-one | CHEMBL91528)
Affinity DataIC50: 6.50E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146050BDBM50146050(3,4,9,10-Tetrahydro-1,7-dioxa-chrysene-2,8-dione |...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146064BDBM50146064(8-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50: 7.30E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29590BDBM29590(1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one | CHEMBL8...)
Affinity DataIC50: 7.40E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146059BDBM50146059(3,4-Dihydro-2H-phenanthren-1-one | CHEMBL88130)
Affinity DataIC50: 8.10E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146053BDBM50146053(Benzo[f]chromen-3-one | CHEMBL424248)
Affinity DataIC50: 8.60E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146061BDBM50146061({2-[2-(3-Oxo-2,3-dihydro-1H-benzo[f]chromen-5-ylox...)
Affinity DataIC50: 8.60E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146049BDBM50146049(3,4,9,10-Tetrahydro-1,12-dioxa-triphenylene-2,11-d...)
Affinity DataIC50: 8.90E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146066BDBM50146066(3-(2-Hydroxy-naphthalen-1-yl)-propionic acid methy...)
Affinity DataIC50: 9.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146056BDBM50146056(5-Hydroxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50: 1.11E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146070BDBM50146070(3,4-dihydro-2H-1-benzopyran-2-one | 3,4-dihydrocou...)
Affinity DataIC50: 1.22E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146057BDBM50146057(N,N-Diethyl-3-(2-hydroxy-naphthalen-1-yl)-propiona...)
Affinity DataIC50: 1.25E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146065BDBM50146065(3-(2-Hydroxy-naphthalen-1-yl)-propionamide | CHEMB...)
Affinity DataIC50: 1.25E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146055BDBM50146055(5-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50: 1.28E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146051BDBM50146051(6-Hydroxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50: 1.31E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent histone deacetylase SIR2(Baker's yeast)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146045BDBM50146045(9-Hydroxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50: 1.34E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed