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Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50014689
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146201(6-Phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5...)
Affinity DataIC50:  0.5nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146201(6-Phenyl-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-5...)
Affinity DataIC50:  1.20nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146206(2-Benzyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1...)
Affinity DataIC50:  4.70nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146200((E)-3-[4-(6-Hydroxy-1-phenyl-3,4-dihydro-1H-isoqui...)
Affinity DataIC50:  4.80nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146223(2-Benzenesulfonyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-...)
Affinity DataIC50:  5.20nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146216(2-(Naphthalene-1-sulfonyl)-1-[4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  5.60nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146200((E)-3-[4-(6-Hydroxy-1-phenyl-3,4-dihydro-1H-isoqui...)
Affinity DataIC50:  5.90nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146222(1-Benzyl-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6...)
Affinity DataIC50:  6.70nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146199((E)-3-[4-(6-Hydroxy-1-phenyl-3,4-dihydro-1H-isoqui...)
Affinity DataIC50:  8nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146199((E)-3-[4-(6-Hydroxy-1-phenyl-3,4-dihydro-1H-isoqui...)
Affinity DataIC50:  8.70nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146220(2,2,2-Trifluoro-1-[(R)-6-hydroxy-1-(4-hydroxy-phen...)
Affinity DataIC50:  8.90nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146205(2-Benzo[1,3]dioxol-5-ylmethyl-1-[4-(2-pyrrolidin-1...)
Affinity DataIC50:  9.20nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146207(4-(4-Hydroxy-phenyl)-2-(naphthalene-1-sulfonyl)-1,...)
Affinity DataIC50:  11nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146211(2,2,2-Trifluoro-1-[7-hydroxy-4-(4-hydroxy-phenyl)-...)
Affinity DataIC50:  11nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20585(2-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1...)
Affinity DataIC50:  12nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146198(2-Benzyl-4-(4-hydroxy-phenyl)-1,2,3,4-tetrahydro-i...)
Affinity DataIC50:  13nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146223(2-Benzenesulfonyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-...)
Affinity DataIC50:  19nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146198(2-Benzyl-4-(4-hydroxy-phenyl)-1,2,3,4-tetrahydro-i...)
Affinity DataIC50:  20nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146216(2-(Naphthalene-1-sulfonyl)-1-[4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  21nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146204(1-[1-(4-Bromo-phenyl)-6-hydroxy-3,4-dihydro-1H-iso...)
Affinity DataIC50:  22nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20585(2-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1...)
Affinity DataIC50:  22nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146208(1-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-2-(toluene...)
Affinity DataIC50:  25nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146221(2-Phenyl-1-thiophen-2-yl-1,2,3,4-tetrahydro-isoqui...)
Affinity DataIC50:  26nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146215(2,2,2-Trifluoro-1-(6-hydroxy-1-phenyl-3,4-dihydro-...)
Affinity DataIC50:  27nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146213(CHEMBL93207 | [7-Hydroxy-4-(4-hydroxy-phenyl)-3,4-...)
Affinity DataIC50:  28nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146207(4-(4-Hydroxy-phenyl)-2-(naphthalene-1-sulfonyl)-1,...)
Affinity DataIC50:  28nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146202(2,2,2-Trifluoro-1-{6-hydroxy-1-[4-(2-pyrrolidin-1-...)
Affinity DataIC50:  29nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146226(2-(4-Propyl-benzenesulfonyl)-1-[4-(2-pyrrolidin-1-...)
Affinity DataIC50:  29nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146209(1-Cyclohexyl-2-phenyl-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataIC50:  30nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146224(1,2-Diphenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol |...)
Affinity DataIC50:  31nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146206(2-Benzyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1...)
Affinity DataIC50:  42nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146225(2-Benzenesulfonyl-4-(4-hydroxy-phenyl)-1,2,3,4-tet...)
Affinity DataIC50:  42nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146212(1-Isopropyl-2-phenyl-1,2,3,4-tetrahydro-isoquinoli...)
Affinity DataIC50:  43nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146219(6-Hydroxy-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-...)
Affinity DataIC50:  44nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146224(1,2-Diphenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol |...)
Affinity DataIC50:  49nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146221(2-Phenyl-1-thiophen-2-yl-1,2,3,4-tetrahydro-isoqui...)
Affinity DataIC50:  50nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146218(1-Cyclohexylmethyl-2-phenyl-1,2,3,4-tetrahydro-iso...)
Affinity DataIC50:  53nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146220(2,2,2-Trifluoro-1-[(R)-6-hydroxy-1-(4-hydroxy-phen...)
Affinity DataIC50:  54nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146214(2,2,2-Trifluoro-1-(6-hydroxy-1-thiophen-2-yl-3,4-d...)
Affinity DataIC50:  64nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146222(1-Benzyl-2-phenyl-1,2,3,4-tetrahydro-isoquinolin-6...)
Affinity DataIC50:  66nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146208(1-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-2-(toluene...)
Affinity DataIC50:  71nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146202(2,2,2-Trifluoro-1-{6-hydroxy-1-[4-(2-pyrrolidin-1-...)
Affinity DataIC50:  93nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146209(1-Cyclohexyl-2-phenyl-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataIC50:  99nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146217(2-(Naphthalene-2-sulfonyl)-1-[4-(2-pyrrolidin-1-yl...)
Affinity DataIC50:  112nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146225(2-Benzenesulfonyl-4-(4-hydroxy-phenyl)-1,2,3,4-tet...)
Affinity DataIC50:  120nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146211(2,2,2-Trifluoro-1-[7-hydroxy-4-(4-hydroxy-phenyl)-...)
Affinity DataIC50:  123nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146226(2-(4-Propyl-benzenesulfonyl)-1-[4-(2-pyrrolidin-1-...)
Affinity DataIC50:  133nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146213(CHEMBL93207 | [7-Hydroxy-4-(4-hydroxy-phenyl)-3,4-...)
Affinity DataIC50:  160nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146204(1-[1-(4-Bromo-phenyl)-6-hydroxy-3,4-dihydro-1H-iso...)
Affinity DataIC50:  165nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor alpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50146212(1-Isopropyl-2-phenyl-1,2,3,4-tetrahydro-isoquinoli...)
Affinity DataIC50:  180nMAssay Description:In vitro concentration required to inhibit [3H]-estradiol binding to human estrogen receptor beta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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