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Found 27 Enz. Inhib. hit(s) with all data for entry = 50015719
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50212314((R)-6-tert-butyl-2-(2-methyl-4-(3-(trifluoromethyl...)
Affinity DataIC50:  32nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50212315((R)-6-tert-butyl-2-(2-methyl-4-(3-methylpyridin-2-...)
Affinity DataIC50:  70nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50212313((R)-6-tert-butyl-2-(4-(3-chloropyridin-2-yl)-2-met...)
Affinity DataIC50:  90nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50212313((R)-6-tert-butyl-2-(4-(3-chloropyridin-2-yl)-2-met...)
Affinity DataIC50:  104nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160308(2-[(R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazi...)
Affinity DataIC50:  113nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160306(6-tert-Butyl-2-[4-(3-chloro-pyridin-2-yl)-piperazi...)
Affinity DataIC50:  136nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160307(5-tert-Butyl-2-[(R)-4-(3-chloro-pyridin-2-yl)-2-me...)
Affinity DataIC50:  305nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160313(6-Chloro-2-[(R)-4-(3-chloro-pyridin-2-yl)-2-methyl...)
Affinity DataIC50:  325nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50212315((R)-6-tert-butyl-2-(2-methyl-4-(3-methylpyridin-2-...)
Affinity DataIC50:  597nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160309(2-[(R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazi...)
Affinity DataIC50:  665nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160301(2-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-5,6-d...)
Affinity DataIC50:  726nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160311(6-tert-Butyl-2-[(R)-4-(4-chloro-[1,2,5]thiadiazol-...)
Affinity DataIC50:  776nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160304(6-tert-Butyl-2-[(S)-4-(3-chloro-pyridin-2-yl)-2-me...)
Affinity DataIC50:  948nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160307(5-tert-Butyl-2-[(R)-4-(3-chloro-pyridin-2-yl)-2-me...)
Affinity DataIC50:  1.41E+3nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160306(6-tert-Butyl-2-[4-(3-chloro-pyridin-2-yl)-piperazi...)
Affinity DataIC50:  1.69E+3nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50212314((R)-6-tert-butyl-2-(2-methyl-4-(3-(trifluoromethyl...)
Affinity DataIC50:  1.78E+3nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160315(5-tert-Butyl-2-[4-(3-chloro-pyridin-2-yl)-piperazi...)
Affinity DataIC50:  2.14E+3nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160314(2-[(R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazi...)
Affinity DataIC50:  3.13E+3nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160304(6-tert-Butyl-2-[(S)-4-(3-chloro-pyridin-2-yl)-2-me...)
Affinity DataIC50:  3.61E+3nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160310(2-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-1,5,6...)
Affinity DataIC50:  5.45E+3nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160302(2-[(S)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazi...)
Affinity DataIC50:  5.77E+3nMAssay Description:Antagonist activity in capsaicin-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160311(6-tert-Butyl-2-[(R)-4-(4-chloro-[1,2,5]thiadiazol-...)
Affinity DataIC50: >1.00E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160315(5-tert-Butyl-2-[4-(3-chloro-pyridin-2-yl)-piperazi...)
Affinity DataIC50: >1.00E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160308(2-[(R)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazi...)
Affinity DataIC50:  1.00E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160301(2-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-5,6-d...)
Affinity DataIC50: >2.50E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160302(2-[(S)-4-(3-Chloro-pyridin-2-yl)-2-methyl-piperazi...)
Affinity DataIC50: >2.50E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50160310(2-[4-(3-Chloro-pyridin-2-yl)-piperazin-1-yl]-1,5,6...)
Affinity DataIC50: >2.50E+4nMpH: 5.5Assay Description:Antagonist activity in pH 5.5-induced FLIPR assays in HEK293 cells expressing human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed