Compile Data Set for Download or QSAR
maximum 50k data
Found 5 Enz. Inhib. hit(s) with all data for entry = 1892
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM14826(1-[5-chloro-2-(tetrahydrofuran-3-yloxy)phenyl]-3-(...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM14827((+/-)1-[5-Chloro-2-(tetrahydro-pyran-4-yloxy)-phen...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM14830((+/-)1-[5-Chloro-2-(3-methyl-oxetan-3-ylmethoxy)-p...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM14829((+/-)1-[5-Chloro-2-(2-dimethylamino-1-methyl-ethyl...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM14828((+/-)1-[5-Chloro-2-(1-methyl-piperidin-4-yloxy)-ph...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed