Compile Data Set for Download or QSAR
maximum 50k data
Found 97 Enz. Inhib. hit(s) with all data for entry = 50016550
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024377(CHEMBL2113037)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170420((4R,5S)-4-(4-Chloro-phenyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  2.40nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170458((4R,5S)-4-(2,4-Dichloro-phenyl)-piperidine-3-carbo...)
Affinity DataIC50:  3.20nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170426((4R,5S)-4-(4-Trifluoromethyl-phenyl)-piperidine-3-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170433((4R,5S)-4-(4-Fluoro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170440((4R,5S)-4-p-Tolyl-piperidine-3-carboxylic acid {(R...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170429((4R,5S)-4-(4-Fluoro-phenyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170447((4R,5S)-4-(2-Fluoro-phenyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  13nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170448((4R,5S)-4-Naphthalen-2-yl-piperidine-3-carboxylic ...)
Affinity DataIC50:  17nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170450((4R,5S)-4-(4-Methoxy-phenyl)-pyrrolidine-3-carboxy...)
Affinity DataIC50:  19nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024372(CHEMBL2113043)
Affinity DataIC50:  22nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024377(CHEMBL2113037)
Affinity DataIC50:  26nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170438(6-(4-Chloro-phenylsulfanyl)-4-((R)-3-{[(4R,5S)-4-(...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170417((4R,5S)-4-p-Tolyl-pyrrolidine-3-carboxylic acid {(...)
Affinity DataIC50:  28nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170441((S)-1-(4-Fluoro-phenyl)-piperazine-2-carboxylic ac...)
Affinity DataIC50:  28nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136514((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Affinity DataIC50:  33nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170428((2S,3S)-3-(2,4-Dichloro-phenyl)-piperidine-4-carbo...)
Affinity DataIC50:  36nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170434((4R,5S)-4-(3-Chloro-phenyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  43nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170455((2S,3S)-3-(4-Cyano-phenyl)-piperidine-4-carboxylic...)
Affinity DataIC50:  45nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170454((4R,5S)-4-(4-Chloro-phenyl)-pyrrolidine-3-carboxyl...)
Affinity DataIC50:  45nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024374(CHEMBL2113039)
Affinity DataIC50:  47nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170445((2S,3S)-3-(4-Chloro-phenyl)-piperidine-4-carboxyli...)
Affinity DataIC50:  58nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170424((4R,5S)-4-(2,4-Difluoro-phenyl)-pyrrolidine-3-carb...)
Affinity DataIC50:  60nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170453((2S,3S)-3-(4-Fluoro-phenyl)-piperidine-4-carboxyli...)
Affinity DataIC50:  66nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170427((4R,5S)-4-(4-Fluoro-phenyl)-pyrrolidine-3-carboxyl...)
Affinity DataIC50:  70nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170425((4R,5S)-4-Naphthalen-1-yl-piperidine-3-carboxylic ...)
Affinity DataIC50:  89nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170457(CHEMBL365675 | Trans 4-(4-Fluoro-phenyl)-piperidin...)
Affinity DataIC50:  93nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136518((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(R...)
Affinity DataIC50:  98nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170461((2S,3S)-3-(2-Fluoro-phenyl)-piperidine-4-carboxyli...)
Affinity DataIC50:  100nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170460((4R,5S)-4-(3-Trifluoromethyl-phenyl)-piperidine-3-...)
Affinity DataIC50:  100nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136530((3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {(R)...)
Affinity DataIC50:  130nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170456((4R,5S)-4-Thiophen-3-yl-piperidine-3-carboxylic ac...)
Affinity DataIC50:  130nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170449((4R,5S)-4-(2-Fluoro-phenyl)-pyrrolidine-3-carboxyl...)
Affinity DataIC50:  160nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170431((2S,3S)-3-(4-Trifluoromethyl-phenyl)-piperidine-4-...)
Affinity DataIC50:  200nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024377(CHEMBL2113037)
Affinity DataIC50:  230nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024374(CHEMBL2113039)
Affinity DataIC50:  290nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170439(6-(4-Chloro-phenylsulfanyl)-4-((R)-3-{[(4S,5R)-4-(...)
Affinity DataIC50:  290nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170419((2R,3S)-3-(4-Fluoro-benzyl)-piperidine-4-carboxyli...)
Affinity DataIC50:  390nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024377(CHEMBL2113037)
Affinity DataIC50:  420nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170459((4R,5S)-4-(3-Fluoro-phenyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  490nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024372(CHEMBL2113043)
Affinity DataIC50:  540nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024373(CHEMBL2113042)
Affinity DataIC50:  560nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024374(CHEMBL2113039)
Affinity DataIC50:  690nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170435((2R,3S)-3-Benzyl-piperidine-4-carboxylic acid {(R)...)
Affinity DataIC50:  750nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024375(CHEMBL2113040)
Affinity DataIC50:  780nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170429((4R,5S)-4-(4-Fluoro-phenyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  840nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170429((4R,5S)-4-(4-Fluoro-phenyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  940nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170463((R)-1-(4-Fluoro-phenyl)-piperazine-2-carboxylic ac...)
Affinity DataIC50:  950nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170464((S)-1-(4-Fluoro-phenyl)-piperazine-2-carboxylic ac...)
Affinity DataIC50:  1.00E+3nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024377(CHEMBL2113037)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of [125I]-NDP- alpha-MSH binding to human melanocortin 5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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