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Found 16 Enz. Inhib. hit(s) with all data for entry = 1528
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11928((1S,3S,5S)-2-{[(2S,4S)-4-[(3-chloro-4-cyanophenyl)...)
Affinity DataKi:  3.60nM ΔG°:  -47.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11920((1S,3S,5S)-2-{[(2S)-3,3-dimethylpyrrolidin-2-yl]ca...)
Affinity DataKi:  37nM ΔG°:  -42.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11927(4-chloro-N-[(3S,5S)-5-{[(1S,3S,5S)-3-cyano-2-azabi...)
Affinity DataKi:  39nM ΔG°:  -41.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11917((1S,3S,5S)-2-[(1S,2S,5R)-3-azabicyclo[3.1.0]hexan-...)
Affinity DataKi:  52nM ΔG°:  -41.2kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11925(9H-fluoren-9-ylmethyl N-[(3S,5S)-5-{[(1S,3S,5S)-3-...)
Affinity DataKi:  57nM ΔG°:  -40.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11919((1S,3S,5S)-2-{[(2S,3S)-3-methylpyrrolidin-2-yl]car...)
Affinity DataKi:  126nM ΔG°:  -39.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11926(N-[(3S,5S)-5-{[(1S,3S,5S)-3-cyano-2-azabicyclo[3.1...)
Affinity DataKi:  133nM ΔG°:  -38.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11923(substituted diprolyl nitrile 16 | tert-butyl N-[(3...)
Affinity DataKi:  140nM ΔG°:  -38.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11921((1S,3S,5S)-2-{[(2S,3S)-3-ethylpyrrolidin-2-yl]carb...)
Affinity DataKi:  290nM ΔG°:  -36.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11914((1S,3S,5S)-2-[(2S)-pyrrolidin-2-ylcarbonyl]-2-azab...)
Affinity DataKi:  305nM ΔG°:  -36.8kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11924(substituted diprolyl nitrile 17 | tert-butyl N-[(3...)
Affinity DataKi:  492nM ΔG°:  -35.6kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11922((1S,3S,5S)-2-{[(2S,3R)-3-(propan-2-yl)pyrrolidin-2...)
Affinity DataKi:  695nM ΔG°:  -34.8kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11918((1S,3S,5S)-2-[(1S,3S,5S)-2-azabicyclo[3.1.0]hexan-...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11916((1S,3S,5S)-2-[(2S)-azetidin-2-ylcarbonyl]-2-azabic...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11913((1S,3S,5S)-2-[(2S)-piperidin-2-ylcarbonyl]-2-azabi...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Sus scrofa (pig))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11915((1S,3S,5S)-2-[(2R)-pyrrolidin-2-ylcarbonyl]-2-azab...)
Affinity DataKi: >1.00E+4nM ΔG°: >-28.3kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed