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Found 32 Enz. Inhib. hit(s) with all data for entry = 50016619
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171275((+)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50241125((+)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition against Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50241125((+)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition against Cytochrome P450 2C9 prepared from baculovirus-infected insect cells using 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171277(CHEMBL195561 | [4-(5-Chloro-2-hydroxy-phenyl)-3-(2...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition against Cytochrome P450 2C9 prepared from baculovirus-infected insect cells using 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50241125((+)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition against Cytochrome P450 2C19 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171284(4-(5-Chloro-2-methoxy-phenyl)-3-(2-hydroxy-ethyl)-...)
Affinity DataIC50:  5.47E+3nMAssay Description:Inhibitory activity against Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50241125((+)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using 7-benzyloxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171282(2-[4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethy...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition against Cytochrome P450 2C19 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171280(4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethyl)-...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition against Cytochrome P450 2C19 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171278(12-Chloro-2-trifluoromethyl-5,7-dihydro-9-oxa-5-az...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibitory activity against Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171277(CHEMBL195561 | [4-(5-Chloro-2-hydroxy-phenyl)-3-(2...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using 7-benzyloxy- 4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171280(4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethyl)-...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using resorufin benzyl etherMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171282(2-[4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethy...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition against Cytochrome P450 2C9 prepared from baculovirus-infected insect cells using 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171277(CHEMBL195561 | [4-(5-Chloro-2-hydroxy-phenyl)-3-(2...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using resorufin benzyl etherMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171280(4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethyl)-...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition against Cytochrome P450 2C9 prepared from baculovirus-infected insect cells using 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171283(2-Chloro-6-(2-oxo-propyl)-11-trifluoromethyl-6,8-d...)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibitory activity against Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171277(CHEMBL195561 | [4-(5-Chloro-2-hydroxy-phenyl)-3-(2...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition against Cytochrome P450 2D6 prepared from baculovirus-infected insect cells using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7- methoxy-4-meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171277(CHEMBL195561 | [4-(5-Chloro-2-hydroxy-phenyl)-3-(2...)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition against Cytochrome P450 2C19 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171282(2-[4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethy...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using 7-benzyloxy- 4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171280(4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethyl)-...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using 7-benzyloxy- 4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50241125((+)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition against Cytochrome P450 1A2 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50241125((+)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition against Cytochrome P450 2D6 prepared from baculovirus-infected insect cells using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171279(4-(5-Chloro-2-hydroxy-phenyl)-3-[3-((S)-diethyl-am...)
Affinity DataIC50:  3.77E+4nMAssay Description:Inhibitory activity against Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171277(CHEMBL195561 | [4-(5-Chloro-2-hydroxy-phenyl)-3-(2...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition against Cytochrome P450 1A2 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171282(2-[4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethy...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using resorufin benzyl etherMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171276(4-(5-Chloro-2-hydroxy-phenyl)-3-[3-((R)-diethyl-am...)
Affinity DataIC50:  5.07E+4nMAssay Description:Inhibitory activity against Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171280(4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethyl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against Cytochrome P450 2D6 prepared from baculovirus-infected insect cells using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7- methoxy-4-meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50241125((+)-4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against Cytochrome P450 3A4 prepared from baculovirus-infected insect cells using resorufin benzyletherMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171281(1-(4-Benzyl-2-oxo-1,2-dihydro-quinolin-3-yl)-pyrid...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against Cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171282(2-[4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against Cytochrome P450 1A2 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171282(2-[4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethy...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against Cytochrome P450 2D6 prepared from baculovirus-infected insect cells using 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7- methoxy-4-meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50171280(4-(5-Chloro-2-hydroxy-phenyl)-3-(2-hydroxy-ethyl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against Cytochrome P450 1A2 prepared from baculovirus-infected insect cells using 3-cyano-7-ethoxycoumarinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed