Compile Data Set for Download or QSAR
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Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 50016791
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173838(4-(4-benzylphenylamino)-6-(2-morpholinoethylamino)...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173834((R)-4-(3-chloro-4-fluorophenylamino)-6-(1-phenylet...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173850(6-(benzylamino)-4-(3-chloro-4-fluorophenylamino)-1...)
Affinity DataIC50:  73nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173837(6-(2-morpholinoethylamino)-4-(4-phenoxyphenylamino...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173851((R)-4-(3-chloro-4-fluorophenylamino)-6-(1-phenylpr...)
Affinity DataIC50:  414nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50173838(4-(4-benzylphenylamino)-6-(2-morpholinoethylamino)...)
Affinity DataIC50:  630nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50173837(6-(2-morpholinoethylamino)-4-(4-phenoxyphenylamino...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50:  960nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM29896(1,7-naphthyridine-3-carbonitrile, 1 | CHEMBL197538)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173844(4-(3-chloro-4-fluorophenylamino)-6-(2-morpholino-1...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173845(4-(3-chloro-4-fluorophenylamino)-6-(3-morpholinopr...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173829(4-(3-chloro-4-fluorophenylamino)-6-(3-(pyrrolidin-...)
Affinity DataIC50:  3.57E+3nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173838(4-(4-benzylphenylamino)-6-(2-morpholinoethylamino)...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173843(4-(3,5-dichlorophenylamino)-6-(2-morpholinoethylam...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173846(4-(4-benzoylphenylamino)-6-(2-morpholinoethylamino...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173841(4-(4-chloro-2-fluorophenylamino)-6-(2-morpholinoet...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173836(4-(3,4-dichlorophenylamino)-6-(2-morpholinoethylam...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM29896(1,7-naphthyridine-3-carbonitrile, 1 | CHEMBL197538)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173831(4-(3-chloro-4-fluorophenylamino)-6-(3-(4-methylpip...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173830((S)-4-(3-chloro-4-fluorophenylamino)-6-(1-phenylet...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173842(6-(2-morpholinoethylamino)-4-(4-(trifluoromethyl)p...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM29896(1,7-naphthyridine-3-carbonitrile, 1 | CHEMBL197538)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173840(4-(3-chloro-4-fluorobenzylamino)-6-(2-morpholinoet...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173839(6-(benzyl(methyl)amino)-4-(3-chloro-4-fluorophenyl...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173835(4-(3-bromo-2-methylphenylamino)-6-(2-morpholinoeth...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173852(4-(3-chloro-4-fluorophenylamino)-6-(cyclopentylami...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173849(6-(2-morpholinoethylamino)-4-(4-(phenylsulfonyl)ph...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173848(4-(4-chlorophenylamino)-6-(2-morpholinoethylamino)...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173847((S)-4-(3-chloro-4-fluorophenylamino)-6-(1-phenylpr...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173837(6-(2-morpholinoethylamino)-4-(4-phenoxyphenylamino...)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173833(6-(2-morpholinoethylamino)-4-(4-(phenylthio)phenyl...)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173837(6-(2-morpholinoethylamino)-4-(4-phenoxyphenylamino...)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM29896(1,7-naphthyridine-3-carbonitrile, 1 | CHEMBL197538)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173838(4-(4-benzylphenylamino)-6-(2-morpholinoethylamino)...)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed