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Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50016929
TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.75nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataIC50:  1.12nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.18nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175413(4-(4-phenyl-5-(trifluoromethyl)isoxazol-3-yl)pheno...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175413(4-(4-phenyl-5-(trifluoromethyl)isoxazol-3-yl)pheno...)
Affinity DataIC50:  8.5nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175412(4-(3-(4-hydroxyphenyl)-1H-indol-2-yl)phenol | CHEM...)
Affinity DataIC50:  11.9nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175417(4-(2-(3-methylisoxazol-4-yl)-1H-benzo[d]imidazol-1...)
Affinity DataIC50:  14.3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175415(4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)p...)
Affinity DataIC50:  15.1nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataIC50:  24nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175410(4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol...)
Affinity DataIC50:  28.1nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  29.4nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175416(4-(2-(thiophen-2-yl)-1H-benzo[d]imidazol-1-yl)phen...)
Affinity DataIC50:  49.7nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175412(4-(3-(4-hydroxyphenyl)-1H-indol-2-yl)phenol | CHEM...)
Affinity DataIC50:  94.8nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175414(4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol | CHEM...)
Affinity DataIC50:  137nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175420(4-(2-(2-chlorophenyl)-1H-benzo[d]imidazol-1-yl)phe...)
Affinity DataIC50:  149nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175411(2,3-diphenyl-1H-indole | CHEMBL200719)
Affinity DataIC50:  171nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175418(4-(3-phenyl-1H-indol-2-yl)phenol | CHEMBL199766)
Affinity DataIC50:  355nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERbeta expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175415(4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)p...)
Affinity DataIC50:  403nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175417(4-(2-(3-methylisoxazol-4-yl)-1H-benzo[d]imidazol-1...)
Affinity DataIC50:  1.16E+3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175420(4-(2-(2-chlorophenyl)-1H-benzo[d]imidazol-1-yl)phe...)
Affinity DataIC50:  1.73E+3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175414(4-(2-phenyl-1H-benzo[d]imidazol-1-yl)phenol | CHEM...)
Affinity DataIC50:  1.80E+3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175410(4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol...)
Affinity DataIC50:  2.94E+3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175416(4-(2-(thiophen-2-yl)-1H-benzo[d]imidazol-1-yl)phen...)
Affinity DataIC50: >6.26E+3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175411(2,3-diphenyl-1H-indole | CHEMBL200719)
Affinity DataIC50:  6.95E+3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175418(4-(3-phenyl-1H-indol-2-yl)phenol | CHEMBL199766)
Affinity DataIC50:  8.31E+3nMAssay Description:Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0100nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175415(4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)p...)
Affinity DataEC50:  6.70nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175410(4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol...)
Affinity DataEC50: >1.00E+3nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175415(4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)p...)
Affinity DataEC50:  243nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175410(4-(2-(1-methyl-1H-pyrrol-2-yl)-1H-benzo[d]imidazol...)
Affinity DataEC50:  40.8nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataEC50:  38.5nMAssay Description:Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEstrogen receptor beta(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.140nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetEstrogen receptor beta(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50175419(4-(2-phenyl-1H-indol-3-yl)phenol | CHEMBL371012)
Affinity DataEC50:  1.09nMAssay Description:Effect on ERbeta in rat ovary granulosa cell line transfected with ER responsive luciferase reporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed