Compile Data Set for Download or QSAR
Report error Found 133 Enz. Inhib. hit(s) with all data for entry = 1517
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11883BDBM11883(1-Cyclopropyl-N-hydroxy-4-{[4-(phenylthio)phenyl]-...)
Affinity DataKi:  0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11870BDBM11870(4-{[4-(4-chlorophenoxy)benzene]sulfonyl}-N-hydroxy...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11873BDBM11873(N-hydroxy-1-methyl-4-[(4-phenoxybenzene)sulfonyl]p...)
Affinity DataKi:  0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11873BDBM11873(N-hydroxy-1-methyl-4-[(4-phenoxybenzene)sulfonyl]p...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11889BDBM11889(N-hydroxy-2-methyl-2-[(4-phenoxybenzene)sulfonyl]p...)
Affinity DataKi:  0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11874BDBM11874(N-hydroxy-1-(2-methoxyethyl)-4-[(4-phenoxybenzene)...)
Affinity DataKi:  0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11874BDBM11874(N-hydroxy-1-(2-methoxyethyl)-4-[(4-phenoxybenzene)...)
Affinity DataKi:  0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11876BDBM11876(1-(Cyclopropylmethyl)-N-hydroxy-4-[(4-phenoxypheny...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11876BDBM11876(1-(Cyclopropylmethyl)-N-hydroxy-4-[(4-phenoxypheny...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11878BDBM11878(1-Acetyl-N-hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11878BDBM11878(1-Acetyl-N-hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-...)
Affinity DataKi: <0.100nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11877BDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  0.130nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11884BDBM11884(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataKi:  0.150nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11870BDBM11870(4-{[4-(4-chlorophenoxy)benzene]sulfonyl}-N-hydroxy...)
Affinity DataKi:  0.150nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11866BDBM11866(N-hydroxy-1-[(3-methoxyphenyl)methyl]-4-{[(4-pheno...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11883BDBM11883(1-Cyclopropyl-N-hydroxy-4-{[4-(phenylthio)phenyl]-...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11871BDBM11871(tert-butyl 4-(hydroxycarbamoyl)-4-[(4-phenoxybenze...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11875BDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11864BDBM11864(tert-Butyl 4-[(Hydroxyamino)carbonyl]-4-{[(4-pheno...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11864BDBM11864(tert-Butyl 4-[(Hydroxyamino)carbonyl]-4-{[(4-pheno...)
Affinity DataKi:  0.200nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11872BDBM11872(N-hydroxy-4-[(4-phenoxybenzene)sulfonyl]piperidine...)
Affinity DataKi:  0.220nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11877BDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  0.220nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11868BDBM11868(CHEMBL256157 | N-hydroxy-4-{[(4-phenoxybenzene)sul...)
Affinity DataKi:  0.25nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11889BDBM11889(N-hydroxy-2-methyl-2-[(4-phenoxybenzene)sulfonyl]p...)
Affinity DataKi:  0.25nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11873BDBM11873(N-hydroxy-1-methyl-4-[(4-phenoxybenzene)sulfonyl]p...)
Affinity DataKi:  0.290nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11882BDBM11882(N-hydroxy-1-(2-methoxyethyl)-4-{[4-(phenylsulfanyl...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11874BDBM11874(N-hydroxy-1-(2-methoxyethyl)-4-[(4-phenoxybenzene)...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11867BDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11875BDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11884BDBM11884(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11871BDBM11871(tert-butyl 4-(hydroxycarbamoyl)-4-[(4-phenoxybenze...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11875BDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11879BDBM11879(N-hydroxy-1-methanesulfonyl-4-[(4-phenoxybenzene)s...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11870BDBM11870(4-{[4-(4-chlorophenoxy)benzene]sulfonyl}-N-hydroxy...)
Affinity DataKi:  0.300nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11885BDBM11885(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataKi:  0.330nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11872BDBM11872(N-hydroxy-4-[(4-phenoxybenzene)sulfonyl]piperidine...)
Affinity DataKi:  0.370nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11885BDBM11885(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11886BDBM11886(1-acetyl-N-hydroxy-4-{[4-(phenylsulfanyl)benzene]s...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11877BDBM11877(N-Hydroxy-4-{[4-(phenoxyphenyl]sulfonyl}-1- (2-pro...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11866BDBM11866(N-hydroxy-1-[(3-methoxyphenyl)methyl]-4-{[(4-pheno...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11863BDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11866BDBM11866(N-hydroxy-1-[(3-methoxyphenyl)methyl]-4-{[(4-pheno...)
Affinity DataKi:  0.400nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11879BDBM11879(N-hydroxy-1-methanesulfonyl-4-[(4-phenoxybenzene)s...)
Affinity DataKi:  0.5nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11880BDBM11880(N-Hydroxy-1-methyl-4-{[4-(phenylthio)phenyl]sulfon...)
Affinity DataKi:  0.5nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11882BDBM11882(N-hydroxy-1-(2-methoxyethyl)-4-{[4-(phenylsulfanyl...)
Affinity DataKi:  0.5nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11868BDBM11868(CHEMBL256157 | N-hydroxy-4-{[(4-phenoxybenzene)sul...)
Affinity DataKi:  0.550nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11875BDBM11875(1-cyclopropyl-N-hydroxy-4-[(4-phenoxybenzene)sulfo...)
Affinity DataKi:  0.600nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11886BDBM11886(1-acetyl-N-hydroxy-4-{[4-(phenylsulfanyl)benzene]s...)
Affinity DataKi:  0.600nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11863BDBM11863(CHEMBL440498 | alpha-tetrahydropyran beta-sulfone ...)
Affinity DataKi:  0.600nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeutrophil collagenase(Human)
Pfizer

LigandChemical structure of BindingDB Monomer ID 11868BDBM11868(CHEMBL256157 | N-hydroxy-4-{[(4-phenoxybenzene)sul...)
Affinity DataKi:  0.600nMAssay Description:Inhibitors were assayed against purified hMMP-1, hMMP-2, hMMP-3, hMMP-8, hMMP-9, and hMMP-13 using an enzyme assay based on cleavage of the quenched ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2006
Entry Details Article
PubMed
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