Compile Data Set for Download or QSAR
maximum 50k data
Found 29 Enz. Inhib. hit(s) with all data for entry = 2744
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  4.40nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24042((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  86nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24040((2R)-2-({4-[4-(1-benzofuran-2-ylcarbonyloxy)phenyl...)
Affinity DataIC50:  350nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24046((2R)-2-[(4-{4-[(E)-2-(1-benzofuran-2-yl)ethenyl]ph...)
Affinity DataIC50:  400nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  700nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24035((2R)-2-[(4-phenylbenzene)sulfonamido]pentanedioic ...)
Affinity DataIC50:  1.10E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24044((2R)-2-({4-[4-(1-benzofuran-2-ylmethoxy)phenyl]ben...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24038((2R)-3-methyl-2-[methyl(4-phenylbenzene)sulfonamid...)
Affinity DataIC50:  1.60E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24037((2R)-3-(1H-indol-2-yl)-2-[(4-phenylbenzene)sulfona...)
Affinity DataIC50:  2.80E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM24025((2R)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50:  3.00E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  3.00E+3nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24045((2R)-2-[(4-{4-[2-(1-benzofuran-2-yl)-2-oxoethyl]ph...)
Affinity DataIC50:  3.80E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24036((2R)-3-phenyl-2-[(4-phenylbenzene)sulfonamido]prop...)
Affinity DataIC50:  4.30E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24031((2R)-2-{[4-(4-hydroxyphenyl)benzene]sulfonamido}-3...)
Affinity DataIC50:  4.60E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24034((2R)-2-[(4-phenylbenzene)sulfonamido]propanoic aci...)
Affinity DataIC50:  5.50E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24043((2R)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50:  7.50E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24030((2R)-2-{[4-(3-hydroxyphenyl)benzene]sulfonamido}-3...)
Affinity DataIC50:  9.00E+3nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24041((2R)-2-({4-[4-(furan-2-ylcarbonyloxy)phenyl]benzen...)
Affinity DataIC50:  1.16E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24039((2R)-3-methyl-2-[(4-phenylbenzene)(pyridin-3-ylmet...)
Affinity DataIC50:  1.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24029((2R)-2-{[4-(2-hydroxyphenyl)benzene]sulfonamido}-3...)
Affinity DataIC50:  2.00E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24027((2R)-2-[(3-amino-4-phenylbenzene)sulfonamido]-3-me...)
Affinity DataIC50:  3.00E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24028((2R)-3-methyl-2-{[4-(2-nitrophenyl)benzene]sulfona...)
Affinity DataIC50:  5.00E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24026((2R)-3-methyl-2-[(3-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24033(4-methyl-3-[(4-phenylbenzene)sulfonamido]pentanoic...)
Affinity DataIC50:  1.00E+5nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24032((2S)-3-methyl-2-[(4-phenylbenzene)sulfonamido]buta...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13139((2S)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DatapH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed