Compile Data Set for Download or QSAR
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Found 15 Enz. Inhib. hit(s) with all data for entry = 50017160
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178415((2S)-2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phe...)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178423(2-((2-(4,5-dichloro-2-(4-fluorophenyl)-6-methoxy-1...)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178418(2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phenyl-2...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178424((2S)-2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phe...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178414(2-(2-((R)-sec-butyl(methyl)amino)ethyl)-4,5-dichlo...)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024404(CHEMBL206698)
Affinity DataIC50:  13nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1 at 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178420((2R)-2-((2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phe...)
Affinity DataIC50:  19nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178426(2-((2-(5,6-dichloro-1,3-dioxo-2-phenyl-2,3-dihydro...)
Affinity DataIC50:  19nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178417(2-((2-(5-chloro-1,3-dioxo-2-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50024405(CHEMBL382386)
Affinity DataIC50:  38nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1 at 3 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178421(2-((2-(4-fluoro-1,3-dioxo-2-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50:  85nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178422(2-((2-(1,3-dioxo-2-phenyl-2,3-dihydro-1H-inden-2-y...)
Affinity DataIC50:  103nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178416((2S)-1-(2-(4,5-dichloro-6-methoxy-1,3-dioxo-2-phen...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178419((2S)-2-((2-(4,5-dichloro-2-(4-fluorophenyl)-6-meth...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50178425(2-((3-(1,3-dioxo-2-phenyl-2,3-dihydro-1H-inden-2-y...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of uptake of [14C]glycine into human JAR cells expressing human GlyT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed