Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50017185
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178775BDBM50178775((S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]in...)
Affinity DataIC50: 63nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178769BDBM50178769(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 98nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178769BDBM50178769(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 98nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178766BDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50: 124nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178773BDBM50178773(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 205nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178787BDBM50178787(7-chloro-1,2,3,4-tetrahydrocyclopenta[b]indole-3-c...)
Affinity DataIC50: 409nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178766BDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50: 652nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178769BDBM50178769(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178767BDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178784BDBM50178784(6-bromo-2,3,4,9-tetrahydro-1H-carbazole-2-carboxam...)
Affinity DataIC50: 2.44E+3nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178773BDBM50178773(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178774BDBM50178774(1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxamid...)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178766BDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50: 2.77E+3nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178767BDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory activity against human SIRT1 by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178773BDBM50178773(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 1.15E+4nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178786BDBM50178786(1,6-dimethyl-2,3,4,9-tetrahydro-1H-carbazole-1-car...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178772BDBM50178772(6-hydroxy-2,3,4,9-tetrahydro-1H-carbazole-1-carbox...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178768BDBM50178768(6-chloro-2,3,4,9-tetrahydro-1H-beta-carboline-1-ca...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178769BDBM50178769(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178776BDBM50178776((R)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]in...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178767BDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibitory activity against recombinant human SIRT2 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178789BDBM50178789(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxa...)
Affinity DataIC50: 3.45E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178769BDBM50178769(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 4.87E+4nMAssay Description:Inhibitory activity against recombinant human SIRT3 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178788BDBM50178788(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-hydroxy...)
Affinity DataIC50: 7.76E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178782BDBM50178782(2-acetyl-6-chloro-2,3,4,9-tetrahydro-1H-beta-carbo...)
Affinity DataIC50: 7.99E+4nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178773BDBM50178773(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against pig brain NAD glycohydrolase (NADase) by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178766BDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT3 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178785BDBM50178785(6-chloro-N,N-diethyl-2,3,4,9-tetrahydro-1H-carbazo...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178771BDBM50178771(6-chloro-N-ethyl-2,3,4,9-tetrahydro-1H-carbazole-1...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178770BDBM50178770(ethyl 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-c...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178766BDBM50178766(2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against pig brain NAD glycohydrolase (NADase) by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178783BDBM50178783(6-chloro-2,3,4,4a,9,9a-hexahydro-1H-carbazole-1-ca...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178767BDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against pig brain NAD glycohydrolase (NADase) by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178773BDBM50178773(6-methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT3 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178781BDBM50178781(N-(2-amino-2-oxoethyl)-6-chloro-2,3,4,9-tetrahydro...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178767BDBM50178767(2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide | CH...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT3 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178769BDBM50178769(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178769BDBM50178769(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxa...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against pig brain NAD glycohydrolase (NADase) by radiochemical Nicotinamide release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178780BDBM50178780(6,9-dimethyl-2,3,4,9-tetrahydro-1H-carbazole-1-car...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178779BDBM50178779(6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178778BDBM50178778(6-bromo-2,3,4,9-tetrahydro-1H-beta-carboline-1-car...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Elixir Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178777BDBM50178777((6-methyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)meth...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against recombinant human SIRT1 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed