Compile Data Set for Download or QSAR
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Report error Found 111 Enz. Inhib. hit(s) with all data for entry = 50017384
TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181395(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  0.120nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataIC50:  0.150nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181395(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  0.220nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181392((R)-N-(3-(3H-spiro[isobenzofuran-1,4'-piperidine]-...)
Affinity DataIC50:  0.270nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50083230(1-((3R,4R)-1-Cyclooctylmethyl-3-hydroxymethyl-pipe...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181374(2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181382(CHEMBL199639 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181374(2-phenoxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pi...)
Affinity DataIC50:  8.20nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181380(CHEMBL413571 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Affinity DataIC50:  8.30nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181380(CHEMBL413571 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181382(CHEMBL199639 | N-[3-spiro(2,3-dihydro-1H-indene-1,...)
Affinity DataIC50:  12nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181366(2-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-piperi...)
Affinity DataIC50:  21nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181378((4R)-3-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-p...)
Affinity DataIC50:  24nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181402((4S,5S)-4-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4...)
Affinity DataIC50:  30nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181379(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  42nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181379(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  47nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181420((2R)-1-benzyl-N-(3-{2,3-dihydrospiro[indene-1,4'-p...)
Affinity DataIC50:  50nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181364(2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-...)
Affinity DataIC50:  83nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181364(2-Benzyloxy-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-...)
Affinity DataIC50:  110nMAssay Description:Antagonist activity on nociceptin-induced [35S]GTPgammaS binding to ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181367(CHEMBL380786 | benzyl (4R)-4-[(3-{2,3-dihydrospiro...)
Affinity DataIC50:  131nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181403(CHEMBL202059 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  170nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181389(CHEMBL202220 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  230nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181390(2-(1,3-benzothiazol-2-ylsulfanyl)-N-(3-{2,3-dihydr...)
Affinity DataIC50:  290nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181381(CHEMBL202604 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  330nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181396(CHEMBL202091 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  340nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181375(CHEMBL426303 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  350nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181426(CHEMBL202094 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  360nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181391(CHEMBL425225 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  540nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181388(CHEMBL201694 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  580nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181400(CHEMBL202575 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  630nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181373((2E)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Affinity DataIC50:  730nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181421(2-(4-chlorophenoxy)-N-(3-{2,3-dihydrospiro[indene-...)
Affinity DataIC50:  870nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181371(CHEMBL383489 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50:  900nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetKappa-type opioid receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181395(1-benzyl-N-[3-spiro(2,3-dihydro-1H-indene-1,4'-pip...)
Affinity DataIC50:  950nMAssay Description:Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181365(CHEMBL381240 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181368(2-(2,3-dihydro-1H-inden-2-yl)-N-(3-{2,3-dihydrospi...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181369(CHEMBL372353 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181370(CHEMBL202438 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181372(CHEMBL201964 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181376(CHEMBL372774 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181377((2R)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181383(CHEMBL202067 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181384(CHEMBL370342 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181385((2Z)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperidine...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181386(CHEMBL372332 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181387(CHEMBL201104 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181393((2S,3R)-N-(3-{2,3-dihydrospiro[indene-1,4'-piperid...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181394(CHEMBL202280 | N-(3-{2,3-dihydrospiro[indene-1,4'-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNociceptin receptor(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50181398(CHEMBL381508 | tert-butyl N-{1-[(3-{2,3-dihydrospi...)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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