Compile Data Set for Download or QSAR
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Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 1990
TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15906(6-chloro-17-methyl-2-oxido-9,15-dioxo-2,14,16,17-t...)
Affinity DataIC50:  290nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15899(9-hydroxy pyrazoloquinolinone 7o | ethyl N-(2-{6-c...)
Affinity DataIC50:  430nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15898(1-(3-{6-chloro-9-hydroxy-1-methyl-4-oxo-1H,4H,9H-p...)
Affinity DataIC50:  500nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15887(3-butyl-6-chloro-9-hydroxy-1-methyl-1H,4H,9H-pyraz...)
Affinity DataIC50:  520nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15896(4-{6-chloro-9-hydroxy-1-methyl-4-oxo-1H,4H,9H-pyra...)
Affinity DataIC50:  750nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15897(9-hydroxy pyrazoloquinolinone 7m | N-(2-{6-chloro-...)
Affinity DataIC50:  780nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15870(6-bromo-9-hydroxy-1,3-dimethyl-1H,4H,9H-pyrazolo[3...)
Affinity DataIC50:  920nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15885(6-chloro-3-ethyl-9-hydroxy-1-methyl-1H,4H,9H-pyraz...)
Affinity DataIC50:  960nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15869(6-chloro-9-hydroxy-1-methyl-3-(trifluoromethyl)-1H...)
Affinity DataIC50:  980nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15868(6-chloro-9-hydroxy-1,3-dimethyl-1H,4H,9H-pyrazolo[...)
Affinity DataIC50:  1.22E+3nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15886(6-chloro-9-hydroxy-1-methyl-3-propyl-1H,4H,9H-pyra...)
Affinity DataIC50:  1.31E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15905(6-chloro-9-hydroxy-3-methyl-1-phenyl-1H,4H,9H-pyra...)
Affinity DataIC50:  1.75E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15892(6-chloro-9-hydroxy-3-(2-methoxyethyl)-1-methyl-1H,...)
Affinity DataIC50:  2.41E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15888(6-chloro-9-hydroxy-1-methyl-3-(propan-2-yl)-1H,4H,...)
Affinity DataIC50:  2.64E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15894(4-{6-chloro-9-hydroxy-1-methyl-4-oxo-1H,4H,9H-pyra...)
Affinity DataIC50:  2.74E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15879(6-chloro-9-ethoxy-1,3-dimethyl-1H,4H,9H-pyrazolo[3...)
Affinity DataIC50:  2.78E+3nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15895(3-(2-aminoethyl)-6-chloro-9-hydroxy-1-methyl-1H,4H...)
Affinity DataIC50:  2.83E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 9(Human)
Abbott Laboratories

LigandPNGBDBM15869(6-chloro-9-hydroxy-1-methyl-3-(trifluoromethyl)-1H...)
Affinity DataIC50:  3.00E+3nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 9(Human)
Abbott Laboratories

LigandPNGBDBM15868(6-chloro-9-hydroxy-1,3-dimethyl-1H,4H,9H-pyrazolo[...)
Affinity DataIC50:  3.10E+3nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15904(6-chloro-1-ethyl-9-hydroxy-3-methyl-1H,4H,9H-pyraz...)
Affinity DataIC50:  4.19E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15900(2-{6-chloro-9-hydroxy-3-methyl-4-oxo-1H,4H,9H-pyra...)
Affinity DataIC50:  4.41E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15878(6-chloro-9-methoxy-1,3-dimethyl-1H,4H,9H-pyrazolo[...)
Affinity DataIC50:  4.59E+3nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15872(6,7-dichloro-9-hydroxy-1-methyl-3-(trifluoromethyl...)
Affinity DataIC50:  5.14E+3nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15880(6-chloro-1,3-dimethyl-9-propoxy-1H,4H,9H-pyrazolo[...)
Affinity DataIC50:  5.43E+3nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15901(9-hydroxy pyrazoloquinolinone 7q | ethyl 2-{6-chlo...)
Affinity DataIC50:  7.64E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15903(6-chloro-9-hydroxy-1-(2-hydroxyethyl)-3-methyl-1H,...)
Affinity DataIC50:  7.67E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15902(2-{6-chloro-9-hydroxy-3-methyl-4-oxo-1H,4H,9H-pyra...)
Affinity DataIC50:  8.77E+3nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15893(3-{6-chloro-9-hydroxy-1-methyl-4-oxo-1H,4H,9H-pyra...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15876(9-hydroxy pyrazoloquinolinone 12b | 9-hydroxy-1,3-...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15877(9-hydroxy pyrazoloquinolinone 12c | 9-hydroxy-1,3-...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15874(6-chloro-7-(dimethylamino)-9-hydroxy-1-methyl-3-(t...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15873(6-chloro-9-hydroxy-8-methoxy-1-methyl-3-(trifluoro...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15884(6-chloro-1,3-dimethyl-1H,4H,9H-pyrazolo[3,4-b]quin...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15871(5,6-dichloro-9-hydroxy-1-methyl-3-(trifluoromethyl...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15883(9-(alk)oxy pyrazoloquinolinone 14f | 9-(benzyloxy)...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15882(6-chloro-9-(cyclopentyloxy)-1,3-dimethyl-1H,4H,9H-...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15881(6-chloro-1,3-dimethyl-9-(propan-2-yloxy)-1H,4H,9H-...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15875(9-hydroxy pyrazoloquinolinone 12a | 9-hydroxy-1,3-...)
Affinity DataIC50: >1.00E+4nMpH: 7.2 T: 20°CAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15889(3-tert-butyl-6-chloro-9-hydroxy-1-methyl-1H,4H,9H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15890(9-hydroxy pyrazoloquinolinone 7f | methyl 6-chloro...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM15891(3-(4-aminophenyl)-6-chloro-9-hydroxy-1-methyl-1H,4...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed