Compile Data Set for Download or QSAR
maximum 50k data
Found 36 Enz. Inhib. hit(s) with all data for entry = 2320
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19386(2,4-diaminopyrimidine derivative, 8b | 6-[(benzylo...)
Affinity DataIC50:  0.200nM EC50:  5.80nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19387(2,4-diaminopyrimidine derivative, 8c | 6-[(benzylo...)
Affinity DataIC50:  0.300nM EC50:  7.20nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19403(2,4-diaminopyrimidine derivative, 11a | 6-[(benzyl...)
Affinity DataIC50:  0.800nM EC50:  16nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19388(2,4-diaminopyrimidine derivative, 8d | 6-[(benzylo...)
Affinity DataIC50:  1nM EC50:  85nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19389(1-(4-{[(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimi...)
Affinity DataIC50:  1.20nM EC50:  10nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19390(2,4-diaminopyrimidine derivative, 8f | 6-[(benzylo...)
Affinity DataIC50:  1.5nM EC50:  3.60nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19377(2,4-diaminopyrimidine derivative, 7c | 5-(4-{[(3,5...)
Affinity DataIC50:  2.40nM EC50:  45nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19391(2,4-diaminopyrimidine derivative, 8g | 4-{[(4-{2,4...)
Affinity DataIC50:  2.80nM EC50:  19nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19392(2,4-diaminopyrimidine derivative, 8h | 6-[(benzylo...)
Affinity DataIC50:  2.90nM EC50:  97nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19409(2,4-diaminopyrimidine derivative, 13 | 6-ethyl-5-(...)
Affinity DataIC50:  3.70nM EC50:  32nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19407(2,4-diaminopyrimidine derivative, 12a | 5-(3-chlor...)
Affinity DataIC50:  4.20nM EC50:  11nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19408(2,4-diaminopyrimidine derivative, 12b | 5-(3-bromo...)
Affinity DataIC50:  5.70nM EC50:  42nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19393(2,4-diaminopyrimidine derivative, 8i | 6-[(benzylo...)
Affinity DataIC50:  6.30nM EC50:  170nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19401(2,4-diaminopyrimidine derivative, 10a | 6-[(benzyl...)
Affinity DataIC50:  6.90nM EC50:  48nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19351(2,4-diaminopyrimidine-based antagonist, 4c | 6-eth...)
Affinity DataIC50:  7.40nM EC50:  12nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19394(2,4-diaminopyrimidine derivative, 8j | 6-[(benzylo...)
Affinity DataIC50:  7.70nM EC50:  90nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19404(2,4-diaminopyrimidine derivative, 11b | 6-ethyl-5-...)
Affinity DataIC50:  9.20nM EC50:  190nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19405(2,4-diaminopyrimidine derivative, 11c | 6-ethyl-5-...)
Affinity DataIC50:  9.80nM EC50:  120nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19378(2,4-diaminopyrimidine derivative, 7d | 6-ethyl-5-(...)
Affinity DataIC50:  11nM EC50:  23nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19380(1-[4-({[4-(2,4-diamino-6-ethylpyrimidin-5-yl)pheny...)
Affinity DataIC50:  13nM EC50:  110nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19385(2,4-diaminopyrimidine derivative, 8a | 6-[(benzylo...)
Affinity DataIC50:  19nM EC50:  180nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19395(2,4-diaminopyrimidine derivative, 8k | 6-[(benzylo...)
Affinity DataIC50:  21nM EC50:  86nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19382(2,4-diaminopyrimidine derivative, 7h | 6-ethyl-5-[...)
Affinity DataIC50:  21nM EC50:  690nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19396(2,4-diaminopyrimidine derivative, 8l | 6-[(benzylo...)
Affinity DataIC50:  43nM EC50:  320nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19397(2,4-diaminopyrimidine derivative, 8m | 5-[4-(benzy...)
Affinity DataIC50:  50nM EC50:  980nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19379(1-[4-({[4-(2,4-diamino-6-ethylpyrimidin-5-yl)pheny...)
Affinity DataIC50:  57nM EC50:  110nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19398(2,4-diaminopyrimidine derivative, 8n | 6-[(benzylo...)
Affinity DataIC50:  67nM EC50:  700nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19402(2,4-diaminopyrimidine derivative, 10b)
Affinity DataIC50:  83nM EC50:  3.61E+3nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19383(2,4-diaminopyrimidine derivative, 7i | 5-(4-{[(2-c...)
Affinity DataIC50:  110nM EC50:  220nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19399(2,4-diaminopyrimidine derivative, 8o | 6-[(benzylo...)
Affinity DataIC50:  130nM EC50:  780nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19381(2,4-diaminopyrimidine derivative, 7g | 4-({[4-(2,4...)
Affinity DataIC50:  160nM EC50:  780nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19384(2,4-diaminopyrimidine derivative, 7j | 5-(4-{[(5-c...)
Affinity DataIC50:  290nM EC50:  790nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19385(2,4-diaminopyrimidine derivative, 8a | 6-[(benzylo...)
Affinity DataIC50:  300nMpH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19406(2,4-diaminopyrimidine derivative, 11d | 5-(4-{[(4-...)
Affinity DataIC50:  300nM EC50:  3.15E+3nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19376(2,4-diaminopyrimidine derivative, 7a | 5-(4-{[(4-c...)
Affinity DataIC50:  310nM EC50:  1.38E+3nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM19400(2,4-diaminopyrimidine derivative, 9 | 5-(4-{[(4-ch...)
Affinity DataIC50:  3.17E+3nM EC50:  3.35E+3nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed