Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 3319
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31288BDBM31288(BMCL163115 Compound 12a | 1,4-benzodiazepine-2,5-d...)
Affinity DataIC50: 250nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31293BDBM31293(BMCL163115 Compound 12e | 1,4-benzodiazepine-2,5-d...)
Affinity DataIC50: 367nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31289BDBM31289(BMCL163115 Compound 12i | 1,4-benzodiazepine-2,5-d...)
Affinity DataIC50: 394nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31314BDBM31314(1,4-benzodiazepine-2,5-dione, 12k)
Affinity DataIC50: 546nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31313BDBM31313(1,4-benzodiazepine-2,5-dione, 12j)
Affinity DataIC50: 787nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31305BDBM31305(BMCL163310 Compound 19 | 1,4-benzodiazepine-2,5-di...)
Affinity DataIC50: 856nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31316BDBM31316(1,4-benzodiazepine-2,5-dione, 12m)
Affinity DataIC50: 1.55E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31310BDBM31310(1,4-benzodiazepine-2,5-dione, 12g)
Affinity DataIC50: 2.39E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31306BDBM31306(1,4-benzodiazepine-2,5-dione, 12c)
Affinity DataIC50: 2.70E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31315BDBM31315(1,4-benzodiazepine-2,5-dione, 12l)
Affinity DataIC50: 5.40E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31307BDBM31307(1,4-benzodiazepine-2,5-dione, 12d)
Affinity DataIC50: 6.25E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31311BDBM31311(1,4-benzodiazepine-2,5-dione, 12h)
Affinity DataIC50: 1.25E+4nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Johnson & Johnson Pharmaceutical

LigandChemical structure of BindingDB Monomer ID 31309BDBM31309(1,4-benzodiazepine-2,5-dione, 12f)
Affinity DataIC50: 1.31E+4nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2009
Entry Details Article
PubMed