Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50017808
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186824BDBM50186824(4'-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170617BDBM50170617(1-(3'-cyano-biphenyl-4-yl)-1-(1-cyclopentyl-piperi...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186837BDBM50186837(4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-f...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186841BDBM50186841(4'-[(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186831BDBM50186831(4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-f...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186834BDBM50186834(4'-[6-cyclopropylmethyl-1-(5-fluoro-6-trifluoromet...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186854BDBM50186854(4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...)
Affinity DataKi:  7.20nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186826BDBM50186826(4'-[6-benzyl-1-(5-fluoro-6-trifluoromethyl-1H-benz...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186846BDBM50186846(4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186849BDBM50186849(5-{4-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5...)
Affinity DataKi:  10nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186830BDBM50186830(4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5,6...)
Affinity DataKi:  15nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186835BDBM50186835(4'-[6-(2-diethylamino-ethyl)-1-(5-fluoro-6-trifluo...)
Affinity DataKi:  15nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186847BDBM50186847(2-{4-[(3'-cyano-biphenyl-4-yl)-(5-fluoro-6-trifluo...)
Affinity DataKi:  16nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186823BDBM50186823(4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186839BDBM50186839(4-[(3'-cyano-biphenyl-4-yl)-(5-fluoro-6-trifluorom...)
Affinity DataKi:  22nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186828BDBM50186828({4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-...)
Affinity DataKi:  26nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186842BDBM50186842(4'-[(1-cyclopropanecarbonyl-piperidin-4-ylidene)-(...)
Affinity DataKi:  31nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186844BDBM50186844(4'-[(1-acetyl-piperidin-4-ylidene)-(5-fluoro-6-tri...)
Affinity DataKi:  31nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186855BDBM50186855(1-(3'-cyano-biphenyl-4-yl)-1-(5-fluoro-6-trifluoro...)
Affinity DataKi:  32nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186833BDBM50186833(4-[(3'-cyano-biphenyl-4-yl)-(5-fluoro-6-trifluorom...)
Affinity DataKi:  37nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186845BDBM50186845([1-(3'-cyano-biphenyl-4-yl)-1-(5-fluoro-6-trifluor...)
Affinity DataKi:  41nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186852BDBM50186852(4'-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol...)
Affinity DataKi:  44nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186848BDBM50186848(4'-[(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...)
Affinity DataKi:  45nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186829BDBM50186829(4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5,6...)
Affinity DataKi:  52nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186858BDBM50186858(4-[(3'-cyano-biphenyl-4-yl)-(5-fluoro-6-trifluorom...)
Affinity DataKi:  64nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186851BDBM50186851(4'-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol...)
Affinity DataKi:  67nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186838BDBM50186838(4'-[(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...)
Affinity DataKi:  71nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186836BDBM50186836(4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-f...)
Affinity DataKi:  77nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186856BDBM50186856(4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(4,6...)
Affinity DataKi:  87nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186827BDBM50186827(2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(4-py...)
Affinity DataKi:  95nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186825BDBM50186825(5-{4-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5...)
Affinity DataKi:  99nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186840BDBM50186840(4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...)
Affinity DataKi:  129nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186850BDBM50186850(2-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(3'-m...)
Affinity DataKi:  132nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186843BDBM50186843(2-[(3'-cyano-biphenyl-4-yl)-(1-cyclopropylmethyl-p...)
Affinity DataKi:  133nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186857BDBM50186857(5-{4-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5...)
Affinity DataKi:  174nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186853BDBM50186853(1-(3'-cyano-biphenyl-4-yl)-1-(5-fluoro-6-trifluoro...)
Affinity DataKi:  221nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50186832BDBM50186832(4'-[(1-cyclopropylmethyl-piperidin-4-ylidene)-(5-f...)
Affinity DataKi:  464nMAssay Description:Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed