Compile Data Set for Download or QSAR
maximum 50k data
Found 24 Enz. Inhib. hit(s) with all data for entry = 50017840
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187218((S)-1-(3,4,5-trichloro-2-hydroxyphenylsulfonyl)pyr...)
Affinity DataIC50:  80nMAssay Description:Cytotoxicity against human Huh7 cell line containing HCV genotype 1b repliconMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187221((4S)-3-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1,...)
Affinity DataIC50:  240nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187232((S)-1-(3-bromo-5-chloro-2-hydroxyphenylsulfonyl)py...)
Affinity DataIC50:  260nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187217(2,4-dichloro-6-{[(2S)-2-(2H-tetrazol-5-yl)pyrrolid...)
Affinity DataIC50:  560nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187228((S)-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)pyrrol...)
Affinity DataIC50:  770nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187233((2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pyr...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187224((4R)-3-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1,...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187230((2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pip...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187222((S)-1-(3-chloro-5-fluoro-2-hydroxyphenylsulfonyl)p...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187225((S)-1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyr...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187229(2,4-dichloro-6-(pyrrolidin-1-ylsulfonyl)phenol | C...)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187220((S)-1-(2-amino-5-chloro-4-methylphenylsulfonyl)pyr...)
Affinity DataIC50:  5.95E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187234((2R)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pip...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187231((R)-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)pyrrol...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187226((S)-1-(3,5-dichlorophenylsulfonyl)pyrrolidine-2-ca...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187227((S)-1-(2-acetamido-5-chloro-4-methylphenylsulfonyl...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187235((S)-methyl 1-(3,5-dichloro-2-hydroxyphenylsulfonyl...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187219((S)-1-(2-benzamido-5-chloro-4-methylphenylsulfonyl...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187223((S)-1-(2-aminophenylsulfonyl)pyrrolidine-2-carboxy...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187225((S)-1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyr...)
Affinity DataIC50: >7.50E+4nMAssay Description:Inhibition of HCV helicaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187225((S)-1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of HIV reverse transcriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187225((S)-1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187225((S)-1-(2-amino-4-chloro-5-methylphenylsulfonyl)pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of calf thymus polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50187218((S)-1-(3,4,5-trichloro-2-hydroxyphenylsulfonyl)pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:Cytotoxicity against human Huh7 cell line containing HCV genotype 1b repliconMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed