BindingDB PrimarySearch

Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50017988

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189584((R)-6-(4-chlorophenyl)-2-(6-(3-(dimethylamino)pyrr...)

Ki: 1.10nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189587((S)-6-(4-chlorophenyl)-2-(6-(3-(dimethylamino)pyrr...)

Ki: 1.10nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189581((S)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrol...)

Ki: 1.20nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189592((R)-2-(4-methoxyphenyl)-6-(6-(3-(methylamino)pyrro...)

Ki: 1.30nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189589((R)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrol...)

Ki: 1.5nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189582((S)-6-(4-chlorophenyl)-2-(6-(3-(pyrrolidin-1-ylami...)

Ki: 1.60nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189579((S)-6-(4-chlorophenyl)-2-(6-(3-(ethylamino)pyrroli...)

Ki: 1.90nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189578((R)-2-(4-chlorophenyl)-6-(6-(3-(methylamino)pyrrol...)

Ki: 1.90nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189593((S)-2-(4-fluorophenyl)-6-(6-(3-(methylamino)pyrrol...)

Ki: 2nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189594((R)-2-(4-fluorophenyl)-6-(6-(3-(methylamino)pyrrol...)

Ki: 2.5nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189591((R)-2-(4-ethylphenyl)-6-(6-(3-(methylamino)pyrroli...)

Ki: 2.60nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189586((S)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)

Ki: 3.10nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189576((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)

Ki: 3.30nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189583((S)-6-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin...)

Ki: 4.40nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189590((S)-2-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)

Ki: 8.40nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189588((R)-2-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)

Ki: 10nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189577(6-(4-methoxy-2-methylphenyl)-2-(6-((S)-3-(methylam...)

Ki: 11nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189585((S)-6-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin...)

Ki: 14nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189580((S)-6-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin...)

Ki: 21nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Muscarinic acetylcholine receptor M3(Human)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189576((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)

Ki: 160nMAssay Description:Binding affinity to muscarinic M3RMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Potassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50170395(Biphenyl-4-carboxylic acid [6-(3-methylamino-pyrro...)

Ki: 200nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Muscarinic acetylcholine receptor M1(Human)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189576((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)

Ki: 260nMAssay Description:Binding affinity to muscarinic M1RMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189576((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)

IC50: 7.70nMAssay Description:Activity at chimeric rat/human MCH1R by accumulation of GTPgammaSMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Melanin-concentrating hormone receptor 1(Rat)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189581((S)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrol...)

IC50: 8.5nMAssay Description:Activity at chimeric rat/human MCH1R by accumulation of GTPgammaSMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Potassium voltage-gated channel subfamily H member 2(Human)
Neurocrine Biosciences

Curated by ChEMBL

BDBM50189576((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)

IC50: 1.80E+3nMAssay Description:Affinity for human ERG channel by patch clamp assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed