Compile Data Set for Download or QSAR
maximum 50k data
Found 147 Enz. Inhib. hit(s) with all data for entry = 50018351
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194684(4-methyl-N-(2-methyl-3-4-methyl-N-(2-methyl-3-(2-(...)
Affinity DataIC50:  0.0100nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194688(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194668(4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM14949(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194691(CHEMBL212128 | N-(4-methyl-3-(2-(methylamino)quina...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194694(CHEMBL427233 | N-(2,3-dihydro-1H-inden-4-yl)-4-met...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194686(1-(2-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)b...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194670(3-(2-aminoquinazolin-6-yl)-4-chloro-N-(3-(trifluor...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194678(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194690(2-fluoro-4-methyl-5-(2-(methylamino)quinazolin-6-y...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194683(CHEMBL212953 | N-(2-(2-(diethylamino)acetamido)-5-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194671(4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194681(CHEMBL215019 | N-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194679(3-(2-aminoquinazolin-6-yl)-4-methyl-N-(2-methyl-3-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194675(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194691(CHEMBL212128 | N-(4-methyl-3-(2-(methylamino)quina...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194700(5-(2-aminoquinazolin-6-yl)-2-fluoro-4-methyl-N-(3-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194672(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194668(4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...)
Affinity DataIC50:  1nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194674(4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(4-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194685(CHEMBL385055 | N-(2-(3,3-dimethyl-2-oxoazetidin-1-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194668(4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Src by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194697(4-methyl-N-(2-(3-methyl-2-oxoimidazolidin-1-yl)-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM14949(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194675(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM35317(4-Methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(3-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194688(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194689(CHEMBL212183 | N-(4-chloro-2-methyl-3-(trifluorome...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194681(CHEMBL215019 | N-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50:  3nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194695(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194668(4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6...)
Affinity DataIC50:  3nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194672(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194697(4-methyl-N-(2-(3-methyl-2-oxoimidazolidin-1-yl)-5-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194676(1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phen...)
Affinity DataIC50:  5nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194691(CHEMBL212128 | N-(4-methyl-3-(2-(methylamino)quina...)
Affinity DataIC50:  5nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194673(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194698(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194688(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM14949(2-aminoquinazoline 5 | 3-(2-aminoquinazolin-6-yl)-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194678(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194673(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194674(4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(4-(...)
Affinity DataIC50:  8nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194684(4-methyl-N-(2-methyl-3-4-methyl-N-(2-methyl-3-(2-(...)
Affinity DataIC50:  8nMAssay Description:Inhibition of KDR by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194676(1-(4-methyl-3-(2-(methylamino)quinazolin-6-yl)phen...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194698(4-methyl-N-(2-methyl-3-(trifluoromethyl)phenyl)-3-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194671(4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(...)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194687(3-(2-(methylamino)quinazolin-6-yl)-N-(3-(trifluoro...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Lck by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50194681(CHEMBL215019 | N-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50:  14nMAssay Description:Inhibition of p38-alpha by HTRF kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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