Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 1555
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12133(3-(Indol-2-yl)indazole 23 | [5-(3-{5-[(4-fluoropip...)
Affinity DataIC50:  0.110nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12134(2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-...)
Affinity DataIC50:  0.25nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12132(3-(Indol-2-yl)indazole 22 | [5-(3-{5-[(4-fluoropip...)
Affinity DataIC50:  0.300nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12131((5-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-...)
Affinity DataIC50:  0.300nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12112(1-[4-({2-[6-(1H-1,2,3,4-tetrazol-5-yl)-1H-indazol-...)
Affinity DataIC50:  2.30nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12126(3-(Indol-2-yl)indazole 16 | 3-[5-(piperidin-1-ylme...)
Affinity DataIC50:  2.60nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12121(3-(Indol-2-yl)indazole 11 | 4-({2-[6-(1H-pyrazol-4...)
Affinity DataIC50:  10nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12116(3-(Indol-2-yl)indazole 6 | 3-[5-(morpholin-4-ylmet...)
Affinity DataIC50:  11nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12118(3-(Indol-2-yl)indazole 8 | 3-[5-(morpholin-4-ylmet...)
Affinity DataIC50:  12nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12124(3-(Indol-2-yl)indazole 14 | 4-{3-[5-(piperidin-1-y...)
Affinity DataIC50:  12nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12119(3-(Indol-2-yl)indazole 9 | N-methyl-3-[5-(morpholi...)
Affinity DataIC50:  13nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12113(3-(Indol-2-yl)indazole 3 | 3-{5-[(4-acetylpiperazi...)
Affinity DataIC50:  17nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12124(3-(Indol-2-yl)indazole 14 | 4-{3-[5-(piperidin-1-y...)
Affinity DataIC50:  18nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12121(3-(Indol-2-yl)indazole 11 | 4-({2-[6-(1H-pyrazol-4...)
Affinity DataIC50:  25nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12111(3-(1H-indol-2-yl)-6-(1H-1,2,3,4-tetrazol-5-yl)-1H-...)
Affinity DataIC50:  27nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12116(3-(Indol-2-yl)indazole 6 | 3-[5-(morpholin-4-ylmet...)
Affinity DataIC50:  30nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12127(3-(Indol-2-yl)indazole 17 | 6-(5-methyl-1H-1,2,3-t...)
Affinity DataIC50:  30nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12123(3-(Indol-2-yl)indazole 13 | 4-({2-[6-(1H-pyrazol-5...)
Affinity DataIC50:  34nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12129(3-(Indol-2-yl)indazole 19 | 3-[5-(piperidin-1-ylme...)
Affinity DataIC50:  34nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12130(3-(Indol-2-yl)indazole 20 | 6-phenyl-3-[5-(piperid...)
Affinity DataIC50:  45nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12125(2-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-i...)
Affinity DataIC50:  48nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12131((5-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-...)
Affinity DataIC50:  56nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12126(3-(Indol-2-yl)indazole 16 | 3-[5-(piperidin-1-ylme...)
Affinity DataIC50:  57nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12123(3-(Indol-2-yl)indazole 13 | 4-({2-[6-(1H-pyrazol-5...)
Affinity DataIC50:  59nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12117(3-(Indol-2-yl)indazole 7 | methyl 3-[5-(morpholin-...)
Affinity DataIC50:  62nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12120(3-(Indol-2-yl)indazole 10 | N,N-dimethyl-3-[5-(mor...)
Affinity DataIC50:  80nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12128(3-(Indol-2-yl)indazole 18 | 3-[5-(piperidin-1-ylme...)
Affinity DataIC50:  110nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12114(1-(4-{[2-(6-chloro-1H-indazol-3-yl)-1H-indol-5-yl]...)
Affinity DataIC50:  120nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12132(3-(Indol-2-yl)indazole 22 | [5-(3-{5-[(4-fluoropip...)
Affinity DataIC50:  180nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12133(3-(Indol-2-yl)indazole 23 | [5-(3-{5-[(4-fluoropip...)
Affinity DataIC50:  300nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12134(2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-...)
Affinity DataIC50:  310nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12127(3-(Indol-2-yl)indazole 17 | 6-(5-methyl-1H-1,2,3-t...)
Affinity DataIC50:  420nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12129(3-(Indol-2-yl)indazole 19 | 3-[5-(piperidin-1-ylme...)
Affinity DataIC50:  480nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12122(3-(Indol-2-yl)indazole 12 | 4-({2-[6-(1-methyl-1H-...)
Affinity DataIC50:  530nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

LigandPNGBDBM12115(1-(4-{[2-(1H-indazol-3-yl)-1H-indol-5-yl]methyl}pi...)
Affinity DataIC50:  640nMpH: 7.5 T: 22°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12118(3-(Indol-2-yl)indazole 8 | 3-[5-(morpholin-4-ylmet...)
Affinity DataIC50:  1.30E+3nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12128(3-(Indol-2-yl)indazole 18 | 3-[5-(piperidin-1-ylme...)
Affinity DataIC50:  2.30E+3nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12125(2-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-i...)
Affinity DataIC50:  4.00E+3nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12119(3-(Indol-2-yl)indazole 9 | N-methyl-3-[5-(morpholi...)
Affinity DataIC50:  4.90E+3nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12117(3-(Indol-2-yl)indazole 7 | methyl 3-[5-(morpholin-...)
Affinity DataIC50:  6.50E+3nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12130(3-(Indol-2-yl)indazole 20 | 6-phenyl-3-[5-(piperid...)
Affinity DataIC50:  7.00E+3nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Merck Research Laboratories

LigandPNGBDBM12120(3-(Indol-2-yl)indazole 10 | N,N-dimethyl-3-[5-(mor...)
Affinity DataIC50: >1.00E+5nMAssay Description:The IMAP technology is based on the high affinity binding of phosphate by immobilized metal coordination complexes on nanoparticles. This IMAP bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed