Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 2086
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16712(5-(2-acetylphenyl)-1-N-[(2S,3R)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 110nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16711(1-N-[(2S,3R)-4-(benzylamino)-3-hydroxy-1-phenylbut...)
Affinity DataIC50: 115nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16713(5-(2-acetylphenyl)-1-N-[(2S,3R)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 115nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16706(5-(2-acetylphenyl)-1-N-[(2S,3R)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 223nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16708(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50: 317nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16714(5-(2-acetylphenyl)-1-N-[(2S,3R)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 348nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16709(1-N-[(2S,3R)-4-[(cyclopropylmethyl)amino]-3-hydrox...)
Affinity DataIC50: 418nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16707(5-(2-acetylphenyl)-1-N-[(2S,3R)-3-hydroxy-1-phenyl...)
Affinity DataIC50: 674nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16710(1-N-[(2S,3R)-4-(cyclobutylamino)-3-hydroxy-1-pheny...)
Affinity DataIC50: 1.40E+3nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16705(5-(2-acetylphenyl)-1-N-[(2S)-1-hydroxy-3-phenylpro...)
Affinity DataIC50: 9.90E+3nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16715(1-N-[(2S,3R)-4-[benzyl(methyl)amino]-3-hydroxy-1-p...)
Affinity DataIC50: 1.00E+4nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16716(1-N-[(2S,3R)-4-(azetidin-1-yl)-3-hydroxy-1-phenylb...)
Affinity DataIC50: 1.00E+4nMpH: 4.5 T: 2°CAssay Description:The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. Test compounds were preincubated with enzymes for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2007
Entry Details Article
PubMed