Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50022544
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataKi:  0.160nMAssay Description:Inhibition of B-Raf (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataKi:  1.70nMAssay Description:Inhibition of c-Raf (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM79601(4-[4-[[[4-chloro-3-(trifluoromethyl)anilino]-oxome...)
Affinity DataKi:  6nMAssay Description:Inhibition of c-Raf (unknown origin) assessed as apparent inhibition constant incubated for 25 mins in presence of gamma-[33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  28nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human COLO 205 cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  58nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human HT-29 cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  58nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human SK-MEL-28 cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  190nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human Malme-3M cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  290nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human A375P cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of B-Raf in human HCT-116 cells expressing K-Ras2 G13D mutant assessed as inhibition of ERK phosphorylation incubated for 60 mins by Weste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of B-Raf in human SK-MEL-2 cells expressing N-Ras Q61R mutant assessed as inhibition of ERK phosphorylation incubated for 60 mins by Weste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  5.10E+3nMAssay Description:Inhibition of B-Raf in human HMEC cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  6.10E+3nMAssay Description:Inhibition of B-Raf in human PrEC cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50:  1.10E+4nMAssay Description:Inhibition of B-Raf in human HFF cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50457452(SB590885 | SB-590885)
Affinity DataEC50: >1.30E+4nMAssay Description:Inhibition of B-Raf in human HT-1080 cells expressing N-Ras2 Q61K mutant assessed as inhibition of ERK phosphorylation incubated for 60 mins by Weste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed