Compile Data Set for Download or QSAR
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Found 15 Enz. Inhib. hit(s) with all data for entry = 2083
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16679(Mixture of trans methyl(cyclopropylmethyl)diastere...)
Affinity DataIC50:  2nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16688(N-[(2S,3R)-3-amino-4-methoxy-1-phenylbutan-2-yl]-2...)
Affinity DataIC50:  6nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16676(Mixture of trans methyl(cyclopropylmethyl)diastere...)
Affinity DataIC50:  9nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16680(Mixture of trans methyl(cyclopropylmethyl)diastere...)
Affinity DataIC50:  11nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16685(N-[(2S,3R)-3-amino-4-methoxy-1-phenylbutan-2-yl]-2...)
Affinity DataIC50:  12nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16675(Mixture of trans methyl(cyclopropylmethyl)diastere...)
Affinity DataIC50:  13nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16678(Mixture of trans methyl(cyclopropylmethyl)diastere...)
Affinity DataIC50:  20nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16687(N-[(2S,3R)-3-amino-4-ethoxy-1-phenylbutan-2-yl]-2-...)
Affinity DataIC50:  24nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16686(N-[(2S,3R)-3-amino-4-methoxy-1-phenylbutan-2-yl]-2...)
Affinity DataIC50:  24nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16682(N-[(2S,3S)-3-amino-1-phenylheptan-2-yl]-2-[methyl(...)
Affinity DataIC50:  31nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16681(Mixture of trans methyl(cyclopropylmethyl)diastere...)
Affinity DataIC50:  32nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16677(Mixture of trans methyl(cyclopropylmethyl)diastere...)
Affinity DataIC50:  34nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16683(N-[(2S,3S)-3-amino-1-phenylheptan-2-yl]-2-[methyl(...)
Affinity DataIC50:  39nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16684(N-[(2S,3S)-3-amino-1-phenylbutan-2-yl]-2-[methyl({...)
Affinity DataIC50:  67nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM16674(N-[(2S)-1-(3,5-difluorophenyl)-3-hydroxypropan-2-y...)
Affinity DataIC50:  74nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed