Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with all data for entry = 2247
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataKi:  0.200nM EC50:  5.10nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18561(7-amino-6-propyl-4-(trifluoromethyl)-1,2-dihydroqu...)
Affinity DataKi:  9nM IC50: 19nM EC50:  83nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18538(8-ethyl-4-(trifluoromethyl)-1H,2H,6H,7H,8H,9H-pyri...)
Affinity DataKi:  11nM ΔG°:  -47.3kJ/mole IC50: 14nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18562(7-amino-6-(butan-2-yl)-4-(trifluoromethyl)-1,2-dih...)
Affinity DataKi:  13nM IC50: 14nM EC50:  65nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18552(7-[(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  15nM ΔG°:  -46.5kJ/mole IC50: 21nM EC50:  905nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18571(6-[(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  16nM IC50: 18nM EC50:  108nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18572(6-[(2,2,3,3,3-pentafluoropropyl)amino]-4-(trifluor...)
Affinity DataKi:  78nM IC50: 17nM EC50:  246nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18560(7-amino-6-ethyl-4-(trifluoromethyl)-1,2-dihydroqui...)
Affinity DataKi:  20nM IC50: 23nM EC50:  593nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18574(6-[(2-methylpropyl)amino]-4-(trifluoromethyl)-1,2-...)
Affinity DataKi:  59nM IC50: 22nM EC50:  404nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18537(8,8-dimethyl-4-(trifluoromethyl)-1H,2H,8H,9H-pyrid...)
Affinity DataKi:  73nM ΔG°:  -42.4kJ/mole IC50: 27nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18575(6-[(2,2-dimethylpropyl)amino]-4-(trifluoromethyl)-...)
Affinity DataKi:  56nM IC50: 27nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18540(7-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-...)
Affinity DataKi:  407nM ΔG°:  -37.9kJ/mole IC50: 28nM EC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18542(7-(ethylamino)-4-(trifluoromethyl)-1,2-dihydroquin...)
Affinity DataKi:  29nM ΔG°:  -44.8kJ/mole IC50: 35nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18541(7-(methylamino)-4-(trifluoromethyl)-1,2-dihydroqui...)
Affinity DataKi:  83nM ΔG°:  -42.0kJ/mole IC50: 30nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18557(7-[ethyl(2,2,2-trifluoroethyl)amino]-4-(trifluorom...)
Affinity DataKi:  30nM ΔG°:  -44.7kJ/mole IC50: 42nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18559(7-amino-6-methyl-4-(trifluoromethyl)-1,2-dihydroqu...)
Affinity DataKi:  30nM IC50: 76nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18539(7-(propylamino)-4-(trifluoromethyl)-1,2-dihydroqui...)
Affinity DataKi:  37nM ΔG°:  -44.1kJ/mole IC50: 32nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18553(7-[(2,2,3,3,3-pentafluoropropyl)amino]-4-(trifluor...)
Affinity DataKi:  36nM ΔG°:  -44.2kJ/mole IC50: 58nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18573(6-(cyclopentylamino)-4-(trifluoromethyl)-1,2-dihyd...)
Affinity DataKi:  74nM IC50: 42nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18549(7-(cyclobutylamino)-4-(trifluoromethyl)-1,2-dihydr...)
Affinity DataKi:  161nM ΔG°:  -40.3kJ/mole IC50: 43nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18567(7-[(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataIC50: 50nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18543(7-(butylamino)-4-(trifluoromethyl)-1,2-dihydroquin...)
Affinity DataKi:  50nM ΔG°:  -43.3kJ/mole IC50: 67nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18544(7-(propan-2-ylamino)-4-(trifluoromethyl)-1,2-dihyd...)
Affinity DataKi:  79nM ΔG°:  -42.2kJ/mole IC50: 56nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18568(7-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataIC50: 63nM EC50:  73nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18545(7-[(2-methylpropyl)amino]-4-(trifluoromethyl)-1,2-...)
Affinity DataKi:  65nM ΔG°:  -42.7kJ/mole IC50: 74nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18546(7-[(2,2-dimethylpropyl)amino]-4-(trifluoromethyl)-...)
Affinity DataKi:  134nM ΔG°:  -40.8kJ/mole IC50: 98nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18547(7-[(2-methylbutan-2-yl)amino]-4-(trifluoromethyl)-...)
Affinity DataKi:  110nM ΔG°:  -41.3kJ/mole IC50: 209nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18570(6-(ethylamino)-4-(trifluoromethyl)-1,2-dihydroquin...)
Affinity DataIC50: 111nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18548(7-[(2-methylbut-3-en-2-yl)amino]-4-(trifluoromethy...)
Affinity DataKi:  118nM ΔG°:  -41.1kJ/mole IC50: 122nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18550(7-(cyclopentylamino)-4-(trifluoromethyl)-1,2-dihyd...)
Affinity DataKi:  1.00E+3nM ΔG°:  -35.6kJ/mole IC50: 149nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18525(N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluoro...)
Affinity DataKi:  151nM IC50: 162nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18566(6-ethyl-7-[(2,2,2-trifluoroethyl)amino]-4-(trifluo...)
Affinity DataKi:  157nM IC50: 216nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18554(7-(benzylamino)-4-(trifluoromethyl)-1,2-dihydroqui...)
Affinity DataKi:  163nM ΔG°:  -40.3kJ/mole IC50: 294nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18558(7-[propyl(2,2,2-trifluoroethyl)amino]-4-(trifluoro...)
Affinity DataKi:  241nM IC50: 549nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18564(6-methyl-7-[(2-methylpropyl)amino]-4-(trifluoromet...)
Affinity DataKi:  650nM IC50: 301nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18556(7-(diethylamino)-4-(trifluoromethyl)-1,2-dihydroqu...)
Affinity DataKi:  463nM ΔG°:  -37.6kJ/mole IC50: 591nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18565(6-ethyl-7-(methylamino)-4-(trifluoromethyl)-1,2-di...)
Affinity DataKi:  869nM IC50: 504nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18551(7-(cyclohexylamino)-4-(trifluoromethyl)-1,2-dihydr...)
Affinity DataKi:  1.00E+3nM ΔG°:  -35.6kJ/mole IC50: 507nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18563(6-methyl-7-(propylamino)-4-(trifluoromethyl)-1,2-d...)
Affinity DataKi:  641nM IC50: 674nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18555(7-(dimethylamino)-4-(trifluoromethyl)-1,2-dihydroq...)
Affinity DataKi:  761nM ΔG°:  -36.3kJ/mole IC50: 1.16E+3nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed