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Found 35 Enz. Inhib. hit(s) with all data for entry = 50019316
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203571(1-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi: <1nMAssay Description:Displacement of [3H]5-hydroxytrytamine from human 5HT1B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203575((1-(3-(7-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203569((1-(3-(7-((5-(2-fluorophenyl)pyridin-2-yl)methoxy)...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203572((1-(4-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203567(1-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]5-hydroxytrytamine from human 5HT1B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203568((1-(4-(6-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203573(1-cyclopentyl-4-(6-((5-(2-fluorophenyl)-1,2,4-oxad...)
Affinity DataKi:  67nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203570(CHEMBL392350 | N-(3-((5-(2-fluorophenyl)-1,2,4-oxa...)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203567(1-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203574((1-(3-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  108nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203576(1-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  134nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203572((1-(4-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  205nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203566((1-(3-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203566((1-(3-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203570(CHEMBL392350 | N-(3-((5-(2-fluorophenyl)-1,2,4-oxa...)
Affinity DataKi:  222nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203576(1-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  261nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203574((1-(3-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi: >300nMAssay Description:Displacement of [3H]5-hydroxytrytamine from human 5HT1B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203567(1-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  394nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203569((1-(3-(7-((5-(2-fluorophenyl)pyridin-2-yl)methoxy)...)
Affinity DataKi:  410nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203576(1-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  414nMAssay Description:Displacement of [3H]5-hydroxytrytamine from human 5HT1B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203571(1-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203574((1-(3-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  525nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203573(1-cyclopentyl-4-(6-((5-(2-fluorophenyl)-1,2,4-oxad...)
Affinity DataKi:  693nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203568((1-(4-(6-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  709nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203566((1-(3-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]5-hydroxytrytamine from human 5HT1B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203571(1-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl)met...)
Affinity DataKi:  1.28E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203575((1-(3-(7-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203572((1-(4-(6-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataKi:  1.49E+3nMAssay Description:Displacement of [3H]5-hydroxytrytamine from human 5HT1B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203566((1-(3-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]NPTS from human GlyT1C expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203568((1-(4-(6-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  32nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203566((1-(3-(7-((5-(4-chlorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  319nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203575((1-(3-(7-((5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  385nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203569((1-(3-(7-((5-(2-fluorophenyl)pyridin-2-yl)methoxy)...)
Affinity DataIC50:  401nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203573(1-cyclopentyl-4-(6-((5-(2-fluorophenyl)-1,2,4-oxad...)
Affinity DataIC50:  531nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203570(CHEMBL392350 | N-(3-((5-(2-fluorophenyl)-1,2,4-oxa...)
Affinity DataIC50:  857nMAssay Description:Inhibition of [3H]glycine uptake at human GlyT2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed