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Found 36 Enz. Inhib. hit(s) with all data for entry = 2249
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18605(6-[bis(2,2,2-trifluoroethyl)amino]-4-(difluorometh...)
Affinity DataKi:  0.400nM EC50:  0.5nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18578(6-[bis(2,2-difluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  0.5nM ΔG°:  -55.2kJ/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18606(6-[bis(2,2,2-trifluoroethyl)amino]-4-chloro-1,2-di...)
Affinity DataKi:  0.5nM EC50:  0.890nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18607(6-[bis(2,2,2-trifluoroethyl)amino]-4-bromo-1,2-dih...)
Affinity DataKi:  0.5nM EC50:  1nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18601(6-[bis(2,2,2-trifluoroethyl)amino]-4-methyl-1,2-di...)
Affinity DataKi:  1.40nM EC50:  0.800nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18588(6-[(2,2-difluoroethyl)(2,2,2-trifluoroethyl)amino]...)
Affinity DataKi:  1.70nM ΔG°:  -52.1kJ/mole EC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18579(6-[(2-chloro-2,2-difluoroethyl)(2,2-difluoroethyl)...)
Affinity DataKi:  2.30nM ΔG°:  -51.3kJ/mole EC50:  0.400nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18589(6-[(2-chloroethyl)(2,2,2-trifluoroethyl)amino]-4-(...)
Affinity DataKi:  2.60nM ΔG°:  -51.0kJ/mole EC50:  0.5nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18584(6-[propan-2-yl(2,2,2-trifluoroethyl)amino]-4-(trif...)
Affinity DataKi:  2.90nM ΔG°:  -50.7kJ/mole EC50:  0.900nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18599(6-[ethyl(3-oxobutan-2-yl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  3.10nM EC50:  5.80nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18612(6-bisalkylamino-2-quinolinone, 8c | 6-{[(2R)-1-chl...)
Affinity DataKi:  5.40nM EC50:  3.70nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18602(6-[bis(2,2,2-trifluoroethyl)amino]-4-ethyl-1,2-dih...)
Affinity DataKi:  5.40nM EC50:  12nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18590(6-[(2,2-dichloroethyl)(2,2,2-trifluoroethyl)amino]...)
Affinity DataKi:  6nM ΔG°:  -48.8kJ/mole EC50:  1.60nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18593(6-[(2-hydroxyethyl)(2,2,2-trifluoroethyl)amino]-4-...)
Affinity DataKi:  6.60nM ΔG°:  -48.6kJ/mole EC50:  7.90nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18580(6-[methyl(2,2,2-trifluoroethyl)amino]-4-(trifluoro...)
Affinity DataKi:  9nM ΔG°:  -47.8kJ/mole EC50:  9.80nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18610(6-[(2,2,2-trifluoroethyl)[(2R)-1,1,1-trifluoroprop...)
Affinity DataKi:  9.20nM EC50:  2.30nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18613(6-bisalkylamino-2-quinolinone, 8d | 6-{[(2S)-1-chl...)
Affinity DataKi:  9.80nM EC50:  3.60nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18614(4-methyl-6-[(2-methylpropyl)(2,2,2-trifluoroethyl)...)
Affinity DataKi:  12nM EC50:  3.20nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18582(6-[propyl(2,2,2-trifluoroethyl)amino]-4-(trifluoro...)
Affinity DataKi:  12nM ΔG°:  -47.0kJ/mole EC50:  1.30nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18585(6-[(2,2-dimethylpropyl)(2,2,2-trifluoroethyl)amino...)
Affinity DataKi:  12nM ΔG°:  -47.0kJ/mole EC50:  1.80nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18598(6-[ethyl(furan-3-ylmethyl)amino]-4-(trifluoromethy...)
Affinity DataKi:  14nM EC50:  2.80nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18596(6-bisalkylamino-2-quinolinone, 6u | ethyl 2-{[2-ox...)
Affinity DataKi:  19nM IC50:  19nM EC50:  20nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18604(6-[bis(2,2,2-trifluoroethyl)amino]-4-(propan-2-yl)...)
Affinity DataKi:  21nM IC50:  2nM EC50:  9.10nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18608(6-[bis(2,2,2-trifluoroethyl)amino]-4-methoxy-1,2-d...)
Affinity DataKi:  23nM IC50:  15nM EC50:  35nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18600(6-[bis(2,2,2-trifluoroethyl)amino]-1,2-dihydroquin...)
Affinity DataKi:  24nM IC50:  1nM EC50:  57nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18587(6-[butan-2-yl(2,2,2-trifluoroethyl)amino]-4-(trifl...)
Affinity DataKi:  29nM ΔG°:  -44.8kJ/mole EC50:  5.90nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18592(6-[(2,2,3,3,3-pentafluoropropyl)(2,2,2-trifluoroet...)
Affinity DataKi:  31nM ΔG°:  -44.6kJ/mole EC50:  2.30nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18583(6-[butyl(2,2,2-trifluoroethyl)amino]-4-(trifluorom...)
Affinity DataKi:  33nM ΔG°:  -44.4kJ/mole EC50:  6.80nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18603(6-[bis(2,2,2-trifluoroethyl)amino]-4-propyl-1,2-di...)
Affinity DataKi:  42nM IC50:  36nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18595(6-[(thiophen-2-ylmethyl)(2,2,2-trifluoroethyl)amin...)
Affinity DataKi:  61nM ΔG°:  -42.8kJ/mole EC50:  12nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18594(6-[benzyl(2,2,2-trifluoroethyl)amino]-4-(trifluoro...)
Affinity DataKi:  79nM ΔG°:  -42.2kJ/mole EC50:  27nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18611(6-[(2,2,2-trifluoroethyl)[(2S)-1,1,1-trifluoroprop...)
Affinity DataKi:  112nM IC50:  20nM EC50:  50nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18591(6-[(2,2,2-trifluoroethyl)(3,3,3-trifluoropropyl)am...)
Affinity DataKi:  116nM ΔG°:  -41.2kJ/mole EC50:  46nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18586(6-[(3,3-dimethylbutyl)(2,2,2-trifluoroethyl)amino]...)
Affinity DataKi:  243nM ΔG°:  -39.3kJ/mole EC50:  81nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18597(2,2,2-trifluoro-N-[2-oxo-4-(trifluoromethyl)-1,2-d...)
Affinity DataKi:  1.00E+3nM IC50:  4.10nM EC50:  22nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18609(6-[bis(2,2,2-trifluoroethyl)amino]-4-hydroxy-1,2-d...)
Affinity DataKi:  1.00E+3nM IC50:  7nM EC50:  83nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed