Compile Data Set for Download or QSAR
Report error Found 52 Enz. Inhib. hit(s) with all data for entry = 50019421
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204580BDBM50204580(N-phenethyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204580BDBM50204580(N-phenethyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204587BDBM50204587((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204590BDBM50204590((S)-6-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-5...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204590BDBM50204590((S)-6-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-5...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204586BDBM50204586(6-(3-methoxy-4-(2-(piperidin-1-yl)ethoxy)phenyl)-5...)
Affinity DataIC50: 8nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204582BDBM50204582(5-phenyl-N-(2-(piperazin-1-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 9nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204583BDBM50204583((S)-(4-ethylpiperazin-1-yl)(4-(5-phenyl-4-((tetrah...)
Affinity DataIC50: 11nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204585BDBM50204585((S)-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)pheny...)
Affinity DataIC50: 11nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204587BDBM50204587((S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204576BDBM50204576(6-(4-morpholinophenyl)-5-phenyl-N-(2-(piperazin-1-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204583BDBM50204583((S)-(4-ethylpiperazin-1-yl)(4-(5-phenyl-4-((tetrah...)
Affinity DataIC50: 13nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204588BDBM50204588(6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl-N-(...)
Affinity DataIC50: 14nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204591BDBM50204591(5-phenyl-N-(2-(piperidin-4-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 14nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204585BDBM50204585((S)-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)ethoxy)pheny...)
Affinity DataIC50: 16nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204576BDBM50204576(6-(4-morpholinophenyl)-5-phenyl-N-(2-(piperazin-1-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204592BDBM50204592(6-(3-methoxy-4-(2-(piperidin-1-yl)ethoxy)phenyl)-5...)
Affinity DataIC50: 22nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204584BDBM50204584((4-(5-phenyl-4-(2-(piperazin-1-yl)ethylamino)furo[...)
Affinity DataIC50: 22nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204589BDBM50204589((S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 24nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204577BDBM50204577(6-(4-(morpholinomethyl)phenyl)-5-phenyl-N-(2-(pipe...)
Affinity DataIC50: 27nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 36nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204586BDBM50204586(6-(3-methoxy-4-(2-(piperidin-1-yl)ethoxy)phenyl)-5...)
Affinity DataIC50: 38nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204575BDBM50204575(6-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-y...)
Affinity DataIC50: 42nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50204582BDBM50204582(5-phenyl-N-(2-(piperazin-1-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 45nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 78nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17714BDBM17714(CHEMBL247272 | 5,6-diphenyl-N-[2-(piperazin-1-yl)e...)
Affinity DataIC50: 81nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204578BDBM50204578(N-tert-butyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)eth...)
Affinity DataIC50: 83nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204584BDBM50204584((4-(5-phenyl-4-(2-(piperazin-1-yl)ethylamino)furo[...)
Affinity DataIC50: 85nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204577BDBM50204577(6-(4-(morpholinomethyl)phenyl)-5-phenyl-N-(2-(pipe...)
Affinity DataIC50: 91nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204575BDBM50204575(6-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-y...)
Affinity DataIC50: 97nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204582BDBM50204582(5-phenyl-N-(2-(piperazin-1-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 98nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204589BDBM50204589((S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 122nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204588BDBM50204588(6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-phenyl-N-(...)
Affinity DataIC50: 148nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17714BDBM17714(CHEMBL247272 | 5,6-diphenyl-N-[2-(piperazin-1-yl)e...)
Affinity DataIC50: 181nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204591BDBM50204591(5-phenyl-N-(2-(piperidin-4-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 332nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204582BDBM50204582(5-phenyl-N-(2-(piperazin-1-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 397nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204581BDBM50204581((R)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 523nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 537nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204592BDBM50204592(6-(3-methoxy-4-(2-(piperidin-1-yl)ethoxy)phenyl)-5...)
Affinity DataIC50: 586nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204578BDBM50204578(N-tert-butyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)eth...)
Affinity DataIC50: 650nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 914nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204582BDBM50204582(5-phenyl-N-(2-(piperazin-1-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 960nMAssay Description:Inhibition of Jak3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204582BDBM50204582(5-phenyl-N-(2-(piperazin-1-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 992nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204581BDBM50204581((R)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)f...)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of Jak3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50204582BDBM50204582(5-phenyl-N-(2-(piperazin-1-yl)ethyl)-6-(4-(2-(pyrr...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 3.27E+3nMAssay Description:Inhibition of ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 4.89E+3nMAssay Description:Inhibition of Jak2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50204579BDBM50204579(N-isopropyl-5-phenyl-6-(4-(2-(pyrrolidin-1-yl)etho...)
Affinity DataIC50: 8.33E+3nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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