Compile Data Set for Download or QSAR
maximum 50k data
Found 23 Enz. Inhib. hit(s) with all data for entry = 50038020
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207130(8-((6,7-dimethoxy-1-methylisoquinolin-4-yl)methyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207121(CHEMBL245648 | N-(4-((8-((6,7-dimethoxyisoquinolin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207123(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-(3-hyd...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207127(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207132(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-isobut...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207131(3-(cyclopropylmethyl)-8-((6,7-dimethoxyisoquinolin...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207137(8-(bicyclo[2.2.1]heptan-2-ylmethyl)-3-isobutyl-1-m...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207125(8-((6,7-dimethoxy-3-methylisoquinolin-4-yl)methyl)...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207124(3-(cyclohexylmethyl)-8-((6,7-dimethoxyisoquinolin-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207126(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207129(3-(3,4-dimethoxybenzyl)-8-((6,7-dimethoxyisoquinol...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207134(3-isobutyl-8-(isoquinolin-4-ylmethyl)-1-methyl-1H-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207128(CHEMBL393913 | N-(4-((8-((6,7-dimethoxyisoquinolin...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207122(3-isobutyl-8-((7-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207136(8-(1-(6,7-dimethoxyisoquinolin-4-yl)ethyl)-3-isobu...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207139(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1,3-diis...)
Affinity DataIC50:  462nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207135(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-isobut...)
Affinity DataIC50:  553nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PDE7A by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PDE4D by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207138(8-([1,3]dioxolo[4,5-g]isoquinolin-8-ylmethyl)-3-is...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Novartis Institutes Of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant PDE4B by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed