Compile Data Set for Download or QSAR
Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50020454
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214034BDBM50214034((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214034BDBM50214034((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214024BDBM50214024((1S,3S)-N1-(6-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50: 3nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214036BDBM50214036((1S,3S)-N1-((5-(difluoromethoxy)-1-methyl-1H-indol...)
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214037BDBM50214037((1S,3S)-N1-(4-methylquinolin-2-yl)-N3-(thiophen-3-...)
Affinity DataIC50: 7nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214052BDBM50214052((1S,3S)-N1-(4-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214035BDBM50214035((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214052BDBM50214052((1S,3S)-N1-(4-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214050BDBM50214050((1S,3S)-N1-(benzo[c][1,2,5]thiadiazol-4-ylmethyl)-...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214030BDBM50214030((1S,3S)-N1-(3,4-dichlorobenzyl)-N3-(7-methoxy-4-me...)
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214046BDBM50214046((1S,3S)-N1-(3-(trifluoromethoxy)benzyl)-N3-(7-meth...)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214068BDBM50214068(6-methoxy-4-methyl-N-(3-(thiophen-3-ylmethylamino)...)
Affinity DataIC50: 15nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214061BDBM50214061((1S,3S)-N1-(benzo[c][1,2,5]thiadiazol-5-ylmethyl)-...)
Affinity DataIC50: 16nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214047BDBM50214047(3-(((1S,3S)-3-(7-methoxy-4-methylquinolin-2-ylamin...)
Affinity DataIC50: 20nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214032BDBM50214032((1S,3S)-N1-(isoquinolin-4-ylmethyl)-N3-(7-methoxy-...)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214053BDBM50214053((1S,3S)-N1-(6-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214049BDBM50214049((1S,3S)-N1-(6-fluoro-4-methoxyquinolin-2-yl)-N3-(t...)
Affinity DataIC50: 26nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214048BDBM50214048((1S,3S)-N1-(2-bromo-5-methoxybenzyl)-N3-(7-methoxy...)
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214066BDBM50214066((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50: 29nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214055BDBM50214055(N4,N4-dimethyl-N2-((1S,3S)-3-(thiophen-3-ylmethyla...)
Affinity DataIC50: 29nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214044BDBM50214044(3-(((1S,3S)-3-(7-methoxy-4-methylquinolin-2-ylamin...)
Affinity DataIC50: 33nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214045BDBM50214045((1S,2S,4R,6S)-N2-(6-methoxy-4-methylquinolin-2-yl)...)
Affinity DataIC50: 35nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214036BDBM50214036((1S,3S)-N1-((5-(difluoromethoxy)-1-methyl-1H-indol...)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214041BDBM50214041(3-(((1S,3S)-3-(7-methoxy-4-methylquinolin-2-ylamin...)
Affinity DataIC50: 39nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214023BDBM50214023((1S,3S)-N1-(5-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214021BDBM50214021((1S,3S)-N1-(2-chloro-4-(methylsulfonyl)benzyl)-N3-...)
Affinity DataIC50: 50nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214023BDBM50214023((1S,3S)-N1-(5-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50: 54nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214053BDBM50214053((1S,3S)-N1-(6-methoxyquinolin-2-yl)-N3-(thiophen-3...)
Affinity DataIC50: 57nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214038BDBM50214038(5-chloro-3-(((1S,3S)-3-(7-methoxy-4-methylquinolin...)
Affinity DataIC50: 58nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214037BDBM50214037((1S,3S)-N1-(4-methylquinolin-2-yl)-N3-(thiophen-3-...)
Affinity DataIC50: 59nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214039BDBM50214039((1S,3S)-N1-((5-bromo-1-methyl-1H-indol-3-yl)methyl...)
Affinity DataIC50: 61nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214040BDBM50214040((1S,3S)-N1-(6-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50: 62nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214025BDBM50214025((1S,3S)-N1-(quinolin-2-yl)-N3-(thiophen-3-ylmethyl...)
Affinity DataIC50: 68nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214057BDBM50214057((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50: 71nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214065BDBM50214065((1S,3S)-N1-((5-(benzyloxy)-1-methyl-1H-indol-3-yl)...)
Affinity DataIC50: 80nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214066BDBM50214066((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50: 83nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214035BDBM50214035((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-((...)
Affinity DataIC50: 85nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214058BDBM50214058((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-(p...)
Affinity DataIC50: 89nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214049BDBM50214049((1S,3S)-N1-(6-fluoro-4-methoxyquinolin-2-yl)-N3-(t...)
Affinity DataIC50: 90nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214055BDBM50214055(N4,N4-dimethyl-N2-((1S,3S)-3-(thiophen-3-ylmethyla...)
Affinity DataIC50: 97nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214063BDBM50214063(N-(3-(6-methoxy-4-methylquinolin-2-ylamino)propyl)...)
Affinity DataIC50: 106nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214044BDBM50214044(3-(((1S,3S)-3-(7-methoxy-4-methylquinolin-2-ylamin...)
Affinity DataIC50: 118nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214033BDBM50214033((1S,3S)-N1-(6-methoxy-4-methylquinolin-2-yl)-N3-me...)
Affinity DataIC50: 119nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214047BDBM50214047(3-(((1S,3S)-3-(7-methoxy-4-methylquinolin-2-ylamin...)
Affinity DataIC50: 127nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214027BDBM50214027((1S,3S)-N1-((1,3-dimethyl-1H-pyrazol-4-yl)methyl)-...)
Affinity DataIC50: 178nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214054BDBM50214054((1S,3S)-N1-(6-isopropoxy-4-methoxyquinolin-2-yl)-N...)
Affinity DataIC50: 231nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214025BDBM50214025((1S,3S)-N1-(quinolin-2-yl)-N3-(thiophen-3-ylmethyl...)
Affinity DataIC50: 234nMAssay Description:Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GTP-gamma-S accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214020BDBM50214020((1R,2S,4S,6S)-N2-(6-methoxy-4-methylquinolin-2-yl)...)
Affinity DataIC50: 369nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214059BDBM50214059((1R,3R)-N1-(6-methoxy-4-methylquinolin-2-yl)-N3-(t...)
Affinity DataIC50: 411nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Astrazeneca R&D MöLndal

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50214067BDBM50214067((1S,3S)-N1-(6-chloroquinolin-2-yl)-N3-(thiophen-3-...)
Affinity DataIC50: 571nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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