Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 2437
LigandPNGBDBM20557(N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl...)
Affinity DataIC50: 0.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20557(N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl...)
Affinity DataIC50: 0.900nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20579(N-{4-[(6-{4-[(1S)-1-[4-(trifluoromethyl)phenyl]eth...)
Affinity DataIC50: 1.80nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20581(N-{4-[(6-{4-[(1R)-1-(4-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50: 2nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20561(N-[4-({6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]py...)
Affinity DataIC50: 2.40nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20577(N-{4-[(6-{4-[(1S)-1-(2-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50: 2.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20577(N-{4-[(6-{4-[(1S)-1-(2-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50: 2.70nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20568(N-[4-({6-[4-(2,2-dimethylpropyl)piperazin-1-yl]pyr...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20583(N-{4-[(6-{4-[1-(4-fluorophenyl)ethyl]piperazin-1-y...)
Affinity DataIC50: 3.10nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20581(N-{4-[(6-{4-[(1R)-1-(4-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50: 3.70nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20573(N-{4-[(6-{4-[(1S)-1-phenylethyl]piperazin-1-yl}pyr...)
Affinity DataIC50: 4.80nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20583(N-{4-[(6-{4-[1-(4-fluorophenyl)ethyl]piperazin-1-y...)
Affinity DataIC50: 4.90nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20582(N-{4-[(6-{4-[(1S)-1-(4-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50: 5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20568(N-[4-({6-[4-(2,2-dimethylpropyl)piperazin-1-yl]pyr...)
Affinity DataIC50: 5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20579(N-{4-[(6-{4-[(1S)-1-[4-(trifluoromethyl)phenyl]eth...)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20573(N-{4-[(6-{4-[(1S)-1-phenylethyl]piperazin-1-yl}pyr...)
Affinity DataIC50: 6nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20582(N-{4-[(6-{4-[(1S)-1-(4-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20578(N-{4-[(6-{4-[(1S)-1-(3-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50: 7nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20570(N-(4-{[6-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]ox...)
Affinity DataIC50: 7.5nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20562(N-[4-({6-[4-(trifluoromethyl)cyclohexyl]pyrimidin-...)
Affinity DataIC50: 10nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20578(N-{4-[(6-{4-[(1S)-1-(3-fluorophenyl)ethyl]piperazi...)
Affinity DataIC50: 16nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20563(N-[4-({6-[4-(trifluoromethyl)piperidin-1-yl]pyrimi...)
Affinity DataIC50: 19nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20575(N-[4-({6-[4-(diphenylmethyl)piperazin-1-yl]pyrimid...)
Affinity DataIC50: 20nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20580(N-{4-[(6-{4-[(1S)-1-(4-methoxyphenyl)ethyl]piperaz...)
Affinity DataIC50: 20nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20574(N-{4-[(6-{4-[(1S)-1-phenylpropyl]piperazin-1-yl}py...)
Affinity DataIC50: 20nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20561(N-[4-({6-[4-(trifluoromethyl)cyclohex-1-en-1-yl]py...)
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20576(N-[4-({6-[4-(2-phenylpropan-2-yl)piperazin-1-yl]py...)
Affinity DataIC50: 29nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20574(N-{4-[(6-{4-[(1S)-1-phenylpropyl]piperazin-1-yl}py...)
Affinity DataIC50: 30nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20580(N-{4-[(6-{4-[(1S)-1-(4-methoxyphenyl)ethyl]piperaz...)
Affinity DataIC50: 39nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20571(N-(4-{[6-(4-benzylpiperazin-1-yl)pyrimidin-4-yl]ox...)
Affinity DataIC50: 39nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20570(N-(4-{[6-(4-phenylpiperazin-1-yl)pyrimidin-4-yl]ox...)
Affinity DataIC50: 43nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20576(N-[4-({6-[4-(2-phenylpropan-2-yl)piperazin-1-yl]py...)
Affinity DataIC50: 45nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20571(N-(4-{[6-(4-benzylpiperazin-1-yl)pyrimidin-4-yl]ox...)
Affinity DataIC50: 93nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20569(N-[4-({6-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]p...)
Affinity DataIC50: 120nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20563(N-[4-({6-[4-(trifluoromethyl)piperidin-1-yl]pyrimi...)
Affinity DataIC50: 330nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20562(N-[4-({6-[4-(trifluoromethyl)cyclohexyl]pyrimidin-...)
Affinity DataIC50: 350nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20569(N-[4-({6-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]p...)
Affinity DataIC50: 380nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20566(N-[4-({6-[4-(propan-2-yl)piperazin-1-yl]pyrimidin-...)
Affinity DataIC50: 1.30E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20575(N-[4-({6-[4-(diphenylmethyl)piperazin-1-yl]pyrimid...)
Affinity DataIC50: 1.40E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20567(N-(4-{[6-(4-tert-butylpiperazin-1-yl)pyrimidin-4-y...)
Affinity DataIC50: 1.50E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20572(N-[4-({6-[4-(2-phenylethyl)piperazin-1-yl]pyrimidi...)
Affinity DataIC50: 3.70E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20564(N-(4-{[6-(morpholin-4-yl)pyrimidin-4-yl]oxy}-1,3-b...)
Affinity DataIC50: 4.00E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20572(N-[4-({6-[4-(2-phenylethyl)piperazin-1-yl]pyrimidi...)
Affinity DataIC50: 4.00E+3nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20565(N-(4-{[6-(piperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-b...)
Affinity DataIC50: 4.00E+3nMpH: 7.4 T: 2°CAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20564(N-(4-{[6-(morpholin-4-yl)pyrimidin-4-yl]oxy}-1,3-b...)
Affinity DataIC50: 4.00E+3nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20565(N-(4-{[6-(piperazin-1-yl)pyrimidin-4-yl]oxy}-1,3-b...)
Affinity DataIC50: 4.00E+3nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20566(N-[4-({6-[4-(propan-2-yl)piperazin-1-yl]pyrimidin-...)
Affinity DataIC50: 4.00E+3nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed
LigandPNGBDBM20567(N-(4-{[6-(4-tert-butylpiperazin-1-yl)pyrimidin-4-y...)
Affinity DataIC50: 4.00E+3nMAssay Description:TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2008
Entry Details Article
PubMed