Compile Data Set for Download or QSAR
maximum 50k data
Found 46 Enz. Inhib. hit(s) with all data for entry = 50020697
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataKi:  40nMAssay Description:Binding affinity at human inactive state Nav1.7 by whole cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216643(CHEMBL248009 | tert-butyl (R)-3-(3-fluorophenyl)-1...)
Affinity DataIC50:  9nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216672(CHEMBL248196 | tert-butyl (R)-3-(2,6-difluoropheny...)
Affinity DataIC50:  14nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216659(CHEMBL248195 | tert-butyl (R)-3-(2,5-difluoropheny...)
Affinity DataIC50:  23nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216642(CHEMBL247829 | tert-butyl (R)-1-((S)-1-isopropyl-2...)
Affinity DataIC50:  32nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216675(CHEMBL247648 | tert-butyl (R)-3-(2-fluoro-6-(trifl...)
Affinity DataIC50:  32nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataIC50:  35nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216644(CHEMBL445940 | tert-butyl (R)-3-(2-fluorophenyl)-1...)
Affinity DataIC50:  44nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216657(CHEMBL391392 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataIC50:  45nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216661(CHEMBL247647 | tert-butyl (R)-3-(3-fluoro-2-(trifl...)
Affinity DataIC50:  65nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216668(CHEMBL248424 | tert-butyl (R)-3-(4-fluorophenyl)-1...)
Affinity DataIC50:  71nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216640(CHEMBL393473 | tert-butyl (R)-1-((R)-1-(cyclopropy...)
Affinity DataIC50:  78nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216651(CHEMBL248254 | tert-butyl (R)-3-(2-fluorophenyl)-1...)
Affinity DataIC50:  87nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216666(CHEMBL399232 | tert-butyl (R)-3-(4-fluorophenyl)-1...)
Affinity DataIC50:  98nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216677(CHEMBL400895 | tert-butyl (R)-1-((R)-1-methyl-2-ox...)
Affinity DataIC50:  125nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216645(CHEMBL400468 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataIC50:  137nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216639(CHEMBL392882 | tert-butyl (R)-1-oxo-3-phenyl-1-((R...)
Affinity DataIC50:  145nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216655(CHEMBL393472 | tert-butyl (R)-1-oxo-1-((R)-2-oxo-1...)
Affinity DataIC50:  150nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216670(CHEMBL394058 | benzyl (R)-1-((R)-1-methyl-2-oxo-5-...)
Affinity DataIC50:  150nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216664(CHEMBL391988 | tert-butyl (R)-1-((R)-1-methyl-2-ox...)
Affinity DataIC50:  192nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216662(CHEMBL400488 | tert-butyl (S)-1-((R)-1-isopropyl-2...)
Affinity DataIC50:  214nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216673(CHEMBL246195 | tert-butyl (R)-1-((R)-1-methyl-2-ox...)
Affinity DataIC50:  238nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216658(CHEMBL245598 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataIC50:  295nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216646(CHEMBL398873 | tert-butyl (R)-2-((R)-1-methyl-2-ox...)
Affinity DataIC50:  375nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216669(2,2-dimethyl-N-[(R)-1-((R)-1-methyl-2-oxo-5-phenyl...)
Affinity DataIC50:  380nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216656(CHEMBL398946 | adamantane-1-carboxylic acid [(R)-1...)
Affinity DataIC50:  420nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216653(CHEMBL248430 | tert-butyl (R)-1-((R)-1-methyl-2-ox...)
Affinity DataIC50:  684nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216654(CHEMBL397518 | tert-butyl (R)-1-((R)-2-oxo-1-(2,2,...)
Affinity DataIC50:  885nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216667(CHEMBL246425 | tert-butyl (R)-1-((R)-1-methyl-2-ox...)
Affinity DataIC50:  978nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216637((R)-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216647(CHEMBL398355 | tert-butyl (R)-3-(1H-imidazol-4-yl)...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216641(CHEMBL245599 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50061212((R)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216665(CHEMBL247640 | N-((R)-1-((R)-1-methyl-2-oxo-5-phen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019192((R)-2-amino-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dih...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216676(CHEMBL247639 | methyl (R)-1-((R)-1-methyl-2-oxo-5-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216650((R)-2-(3,3-dimethylbutylamino)-N-((R)-1-methyl-2-o...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216660(CHEMBL247823 | tert-butyl (R)-1-((R)-1-methyl-2,3,...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216652(CHEMBL247656 | tert-butyl (R)-1-((R)-1-methyl-2-ox...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216638(CHEMBL246194 | tert-butyl (R)-3-cyclohexyl-1-((R)-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216648(CHEMBL247999 | tert-butyl (R)-1-((R)-1-methyl-2-ox...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216649(CHEMBL247592 | tert-butyl methyl((R)-1-((R)-1-meth...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216663((R)-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216674((R)-N-((R)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Blockade of human Nav1.7 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216642(CHEMBL247829 | tert-butyl (R)-1-((S)-1-isopropyl-2...)
Affinity DataIC50:  1.73E+3nMAssay Description:Displacement of [3H]diltiazem from human Cav1.2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataIC50:  3.50E+3nMAssay Description:Displacement of [3H]diltiazem from human Cav1.2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed