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Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 2245
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18161((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)
Affinity DataKi:  0.200nM ΔG°:  -57.6kJ/mole EC50:  5.10nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18522(6-(1-Pyrrolidine)quinolin-2(1H)-one, 6a | 6-[(2R,5...)
Affinity DataKi:  1.5nM ΔG°:  -52.4kJ/mole EC50:  7.10nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  4.60nM ΔG°:  -49.5kJ/mole EC50:  0.200nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18523(6-(1-Pyrrolidine)quinolin-2(1H)-one, 6b | 6-[(2R,5...)
Affinity DataKi:  7.60nM ΔG°:  -48.2kJ/mole EC50:  8.40nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18521(6-(1-Pyrrolidine)quinolin-2(1H)-one, 4f | 6-[(2R,5...)
Affinity DataKi:  10nM ΔG°:  -47.5kJ/mole EC50:  12nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18518(6-(1-Pyrrolidine)quinolin-2(1H)-one, 4c | 6-[(2R,5...)
Affinity DataKi:  19nM ΔG°:  -45.8kJ/mole EC50:  2.60nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18519(6-(1-Pyrrolidine)quinolin-2(1H)-one, 4d (+/-) | 6-...)
Affinity DataKi:  43nM ΔG°:  -43.7kJ/mole EC50:  48nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataKi:  70nM ΔG°:  -42.5kJ/mole IC50:  128nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18520(6-(1-Pyrrolidine)quinolin-2(1H)-one, 4e | 6-[(2R,5...)
Affinity DataKi:  70nM ΔG°:  -42.5kJ/mole EC50:  21nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18517(6-(1-Pyrrolidine)quinolin-2(1H)-one, 4b(+/-) | 6-(...)
Affinity DataKi:  72nM ΔG°:  -42.4kJ/mole EC50:  13nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18516(6-(1-Pyrrolidine)quinolin-2(1H)-one, 4a | 6-(pyrro...)
Affinity DataKi:  1.70E+3nM ΔG°:  -34.3kJ/mole IC50:  25nMpH: 7.4 T: 37°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetALK tyrosine kinase receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: >2nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)