Compile Data Set for Download or QSAR
maximum 50k data
Report error Found 67 Enz. Inhib. hit(s) with all data for entry = 2292
TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18991(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.0700nM ΔG°:  -57.4kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19010(6-(4-{2-[(diethylamino)methyl]phenyl}phenyl)-1-(4-...)
Affinity DataKi:  0.0800nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19023(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Affinity DataKi:  0.0800nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19008(1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]p...)
Affinity DataKi:  0.140nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM12743(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.180nM ΔG°:  -55.1kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19020(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Affinity DataKi:  0.230nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19009(6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-1-(4...)
Affinity DataKi:  0.240nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18988(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.25nM ΔG°:  -54.3kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19004(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.25nM ΔG°:  -54.3kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19012(6-(4-{2-[(4-hydroxypiperidin-1-yl)methyl]phenyl}ph...)
Affinity DataKi:  0.290nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19011(1-(4-methoxyphenyl)-7-oxo-6-{4-[2-(pyrrolidin-1-yl...)
Affinity DataKi:  0.300nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18999(3-(dimethylamino)-6-[4-(2-{[(3R)-3-hydroxypyrrolid...)
Affinity DataKi:  0.310nM ΔG°:  -53.7kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18994(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.330nM ΔG°:  -53.6kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19013(6-[4-(2-{[bis(2-hydroxyethyl)amino]methyl}phenyl)p...)
Affinity DataKi:  0.360nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19021(1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Affinity DataKi:  0.470nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19003(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.480nM ΔG°:  -52.7kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19017(N-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Affinity DataKi:  0.5nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19022(1-(4-methoxyphenyl)-6-[4-(N-methylacetamido)phenyl...)
Affinity DataKi:  0.610nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19001(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.630nM ΔG°:  -52.0kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19002(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.670nM ΔG°:  -51.8kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19005(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  0.850nM ΔG°:  -51.3kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19007(6-{4-[2-(aminomethyl)phenyl]phenyl}-1-(4-methoxyph...)
Affinity DataKi:  0.970nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19006(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  1.10nM ΔG°:  -50.6kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18998(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18993(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18997(Pyrazolopyridinone analogue, 23 | tert-butyl N-{6-...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19019(1-(4-methoxyphenyl)-6-[4-(piperidin-1-yl)phenyl]-3...)
Affinity DataKi:  2.10nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19000(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  2.30nM ΔG°:  -48.8kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18989(Pyrazolopyridinone analogue, 11b | ethyl 6-[4-(2-{...)
Affinity DataKi:  3.90nM ΔG°:  -47.5kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18992(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  4.80nM ΔG°:  -47.0kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19018(6-[4-(dimethylamino)phenyl]-1-(4-methoxyphenyl)-3-...)
Affinity DataKi:  6nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18996(3-amino-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]me...)
Affinity DataKi:  6.70nM ΔG°:  -46.2kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18990(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  7.60nM ΔG°:  -45.9kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM18995(Pyrazolopyridinone analogue, 21 | tert-butyl N-{6-...)
Affinity DataKi:  9.60nM ΔG°:  -45.3kJ/molepH: 7.0 T: 22°CAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM18994(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  100nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM18991(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  140nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19015(N-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Affinity DataKi:  180nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM18988(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  180nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM12743(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  330nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19016(1-(4-methoxyphenyl)-6-[4-(methylamino)phenyl]-3-(t...)
Affinity DataKi:  610nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM18997(Pyrazolopyridinone analogue, 23 | tert-butyl N-{6-...)
Affinity DataKi:  950nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM19005(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  970nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM18989(Pyrazolopyridinone analogue, 11b | ethyl 6-[4-(2-{...)
Affinity DataKi:  980nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM19003(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  980nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM19006(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  1.00E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Bristol-Myers Squibb

LigandPNGBDBM19014(6-(4-aminophenyl)-1-(4-methoxyphenyl)-3-(trifluoro...)
Affinity DataKi:  1.60E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM18999(3-(dimethylamino)-6-[4-(2-{[(3R)-3-hydroxypyrrolid...)
Affinity DataKi:  1.80E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM19004(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi:  1.90E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM19000(6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phe...)
Affinity DataKi: >2.50E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Bristol-Myers Squibb

LigandPNGBDBM19022(1-(4-methoxyphenyl)-6-[4-(N-methylacetamido)phenyl...)
Affinity DataKi:  2.52E+3nMAssay Description:Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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