Compile Data Set for Download or QSAR
maximum 50k data
Found 39 Enz. Inhib. hit(s) with all data for entry = 50021555
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225795((E)-3-(8-(cyanomethoxy)-4-oxo-7-(2-phenylethynyl)-...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225793((E)-N-tert-butyl-2-(4-(3-cyanophenyl)-2-oxo-8-(2-p...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225811((E)-4-phenyl-8-(2-phenylethynyl)-1H-benzo[b][1,4]d...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225826((E)-3-(8-(2-methoxyethoxy)-4-oxo-7-(2-phenylethyny...)
Affinity DataIC50:  28nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225821((E)-3-(7-(2-(2-fluorophenyl)ethynyl)-4-oxo-4,5-dih...)
Affinity DataIC50:  30nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225803((E)-3-(4-oxo-7-(2-(thiophen-2-yl)ethynyl)-4,5-dihy...)
Affinity DataIC50:  32nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225814((E)-3-(4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-be...)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225809((E)-3-(7-(2-(4-fluorophenyl)ethynyl)-4-oxo-4,5-dih...)
Affinity DataIC50:  34nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225800((E)-3-(4-oxo-7-(2-phenylethynyl)-8-thiomorpholino-...)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225817((E)-3-(8-(dimethylamino)-4-oxo-7-(2-phenylethynyl)...)
Affinity DataIC50:  60nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225807((E)-3-(4-oxo-7-(2-p-tolylethynyl)-4,5-dihydro-3H-b...)
Affinity DataIC50:  64nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225798((E)-3-(7-(2-(4-methoxyphenyl)ethynyl)-4-oxo-4,5-di...)
Affinity DataIC50:  68nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225801((E)-3-(7-(2-(2-chlorophenyl)ethynyl)-4-oxo-4,5-dih...)
Affinity DataIC50:  76nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225805((E)-4-(3-chlorophenyl)-8-(2-phenylethynyl)-1H-benz...)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225796((E)-3-(8-(4-methoxypiperidin-1-yl)-4-oxo-7-(2-phen...)
Affinity DataIC50:  82nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225812((E)-3-(8-methoxy-4-oxo-7-(2-phenylethynyl)-4,5-dih...)
Affinity DataIC50:  92nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225802((E)-4-(3-iodophenyl)-8-(2-phenylethynyl)-1H-benzo[...)
Affinity DataIC50:  154nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225825(3-[8-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)-4-oxo...)
Affinity DataIC50:  160nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225804(8-(2-phenylethynyl)-4-(3-(trifluoromethyl)phenyl)-...)
Affinity DataIC50:  268nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225820((E)-3-(8-(4-methylpiperazin-1-yl)-4-oxo-7-(2-pheny...)
Affinity DataIC50:  278nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225824((E)-3-(4-oxo-7-(2-(thiazol-2-yl)ethynyl)-4,5-dihyd...)
Affinity DataIC50:  300nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225823((E)-3-(4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-be...)
Affinity DataIC50:  358nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225819((E)-4-(3-(morpholine-4-carbonyl)phenyl)-8-(2-pheny...)
Affinity DataIC50:  360nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225816((E)-3-(8-morpholino-4-oxo-7-(2-phenylethynyl)-4,5-...)
Affinity DataIC50:  378nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225806((E)-3-(7-(3-methylbut-3-en-1-ynyl)-4-oxo-4,5-dihyd...)
Affinity DataIC50:  400nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225808(3-[4-oxo-8-(1-oxo-1lambda4-thiomorpholin-4-yl)-7-p...)
Affinity DataIC50:  446nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225827((E)-3-(7-(2-(2,4-difluorophenyl)ethynyl)-4-oxo-4,5...)
Affinity DataIC50:  480nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225794((E)-2-(4-(3-cyanophenyl)-2-oxo-8-(2-phenylethynyl)...)
Affinity DataIC50:  600nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225815((E)-3-(4-oxo-7-(2-(pyridin-2-yl)ethynyl)-4,5-dihyd...)
Affinity DataIC50:  870nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225813((E)-4-(3-methoxyphenyl)-8-(2-phenylethynyl)-1H-ben...)
Affinity DataIC50:  962nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225818((E)-4-(3-(1-methylpiperazine-4-carbonyl)phenyl)-8-...)
Affinity DataIC50:  1.04E+3nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225799((E)-8-methyl-4-(3-(trifluoromethyl)phenyl)-1H-benz...)
Affinity DataIC50:  1.53E+3nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225797((E)-2-(4-(3-cyanophenyl)-2-oxo-8-(2-phenylethynyl)...)
Affinity DataIC50:  2.40E+3nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225791((E)-4-(3-chlorophenyl)-8-methyl-1H-benzo[b][1,4]di...)
Affinity DataIC50:  2.82E+3nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225822((E)-3-(7-methyl-4-oxo-4,5-dihydro-3H-benzo[b][1,4]...)
Affinity DataIC50:  2.90E+3nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50080063(1-[(Z)-2-(2,4-Dichloro-phenyl)-2-isopropoxy-vinyl]...)
Affinity DataIC50:  6.00E+3nMAssay Description:Antagonist activity at rat mGlu2 expressed in CHO cells assessed as inibition of (1S,3R)-ACPD-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225792((E)-4-(3-methoxyphenyl)-8-methyl-1H-benzo[b][1,4]d...)
Affinity DataIC50:  6.58E+3nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50225810((E)-3-(7-(3-hydroxy-3-methylbut-1-ynyl)-4-oxo-4,5-...)
Affinity DataIC50:  2.60E+4nMAssay Description:Displacement of [3H]LY354740 from rat mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50078227(1-[2-(2,6-dichloro-phenyl)-7-methyl-5H-thiazolo[3,...)
Affinity DataIC50:  3.00E+4nMAssay Description:Antagonist activity at rat mGlu2 expressed in CHO cells assessed as inibition of (1S,3R)-ACPD-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed