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Found 80 Enz. Inhib. hit(s) with all data for entry = 50021587
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataKi:  970nMAssay Description:Binding affinity to rat 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to rat alpha1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to human muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to human alpha2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to human histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataKi: >4.00E+3nMAssay Description:Displacement of dofetilide from hERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1B) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to dopamine D5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to dopamine D1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataIC50: >2.00E+4nMAssay Description:Antagonist activity at human recombinant 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226003((S)-2-fluoro-5-(4-propylmorpholin-2-yl)phenol | CH...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226004(3-(4-propylmorpholin-2-yl)benzenamine | CHEMBL4009...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-...)
Affinity DataEC50:  83nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226007(2-fluoro-5-(4-propylmorpholin-2-yl)phenol | CHEMBL...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226005(3-(4-(2-methoxyethyl)morpholin-2-yl)phenol | CHEMB...)
Affinity DataEC50: >3.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226006(2-(hydroxymethyl)-5-(4-propylmorpholin-2-yl)phenol...)
Affinity DataEC50: >5.90E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226003((S)-2-fluoro-5-(4-propylmorpholin-2-yl)phenol | CH...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226009(3-(morpholin-2-yl)phenol | CHEMBL401328)
Affinity DataEC50:  7.20E+3nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226004(3-(4-propylmorpholin-2-yl)benzenamine | CHEMBL4009...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226010(CHEMBL251216 | N-(4-(2-(3-hydroxyphenyl)morpholino...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226011(4-(4-propylmorpholin-2-yl)-2-(4H-1,2,4-triazol-4-y...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226012((R)-5-(4-propylmorpholin-2-yl)benzene-1,3-diol | C...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226015(1-(2-hydroxy-5-(4-propylmorpholin-2-yl)phenyl)etha...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226013((S)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL24859...)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226014(2-(3-(4H-1,2,4-triazol-3-yl)phenyl)-4-propylmorpho...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226016(3-hydroxy-5-(4-propylmorpholin-2-yl)benzamide | CH...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226017(3-(4-ethylmorpholin-2-yl)phenol | CHEMBL251215)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50002129(2-(3-Chloro-phenyl)-4-propyl-morpholine | 2-(3-chl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226018(2-(3-(methylsulfonyl)phenyl)-4-propylmorpholine | ...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50002129(2-(3-Chloro-phenyl)-4-propyl-morpholine | 2-(3-chl...)
Affinity DataEC50: >2.80E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226019(2-(3-(methylthio)phenyl)-4-propylmorpholine | CHEM...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226020(4-bromo-3-(4-propylmorpholin-2-yl)phenol | CHEMBL2...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226023(2-hydroxy-5-(4-propylmorpholin-2-yl)benzonitrile |...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226022(4-propyl-2-(3-(trifluoromethoxy)phenyl)morpholine ...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226021((3-(4-propylmorpholin-2-yl)phenyl)methanol | CHEMB...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226025((R)-2-fluoro-5-(4-propylmorpholin-2-yl)phenol | CH...)
Affinity DataEC50:  36nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226026(2-hydroxy-5-(4-propylmorpholin-2-yl)benzamide | CH...)
Affinity DataEC50:  427nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226005(3-(4-(2-methoxyethyl)morpholin-2-yl)phenol | CHEMB...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226027(3-(4-propylmorpholin-2-yl)benzamide | CHEMBL250830)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50020680(4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50016017((5aR,9aR)-6-Propyl-5,5a,6,7,8,9,9a,10-octahydro-py...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226024(3-hydroxy-5-(4-propylmorpholin-2-yl)benzonitrile |...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226017(3-(4-ethylmorpholin-2-yl)phenol | CHEMBL251215)
Affinity DataEC50:  547nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226018(2-(3-(methylsulfonyl)phenyl)-4-propylmorpholine | ...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226030((S)-5-(4-propylmorpholin-2-yl)benzene-1,3-diol | C...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226012((R)-5-(4-propylmorpholin-2-yl)benzene-1,3-diol | C...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226031(CHEMBL249794 | N-(2-hydroxy-5-(4-propylmorpholin-2...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226030((S)-5-(4-propylmorpholin-2-yl)benzene-1,3-diol | C...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226029(2-methyl-3-(4-propylmorpholin-2-yl)phenol | CHEMBL...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226008((R)-3-(4-propylmorpholin-2-yl)phenol | CHEMBL25040...)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50226028(2-(3-(1H-imidazol-2-yl)phenyl)-4-propylmorpholine ...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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