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Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 2422
LigandPNGBDBM20286(5-I-RTX | 5-iodoresiniferatoxin | [(1R,2R,6R,10S,1...)
Affinity DataKi:  0.610nM ΔG°:  -54.7kJ/mole EC50:  12.2nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20314((2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-c...)
Affinity DataKi:  1.83nM ΔG°:  -51.9kJ/mole EC50:  5.20nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20311((2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-c...)
Affinity DataKi:  3.29nM ΔG°:  -50.4kJ/mole EC50:  12.1nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20291(2-[(4-tert-butylphenyl)methyl]-3-[2-(3-chloro-4-me...)
Affinity DataKi:  3.60nM ΔG°:  -50.1kJ/mole EC50:  12.3nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20313((2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-f...)
Affinity DataKi:  4.12nM ΔG°:  -49.8kJ/mole EC50:  0.580nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20310((2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-f...)
Affinity DataKi:  6.26nM ΔG°:  -48.7kJ/mole EC50:  10.9nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20297(3-[2-(3-chloro-4-methanesulfonamidophenyl)propanam...)
Affinity DataKi:  11.3nM ΔG°:  -47.2kJ/mole EC50:  36nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20290(2-[(4-tert-butylphenyl)methyl]-3-[2-(3-fluoro-4-me...)
Affinity DataKi:  13.6nM ΔG°:  -46.7kJ/mole EC50:  3.24nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20306((2S)-2-benzyl-3-[(2S)-2-(3-fluoro-4-methanesulfona...)
Affinity DataKi:  16.5nM ΔG°:  -46.2kJ/mole EC50:  10nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20287(2-[(4-tert-butylphenyl)methyl]-3-({[(3-fluoro-4-me...)
Affinity DataKi:  22.6nM ΔG°:  -45.4kJ/mole EC50:  52nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20292(2-[(4-tert-butylphenyl)methyl]-3-[2-(4-methanesulf...)
Affinity DataKi:  24nM ΔG°:  -45.2kJ/molepH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20296(2-[(3,4-dimethylphenyl)methyl]-3-[2-(3-fluoro-4-me...)
Affinity DataKi:  33.1nM ΔG°:  -44.4kJ/mole EC50:  10.8nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20308((2R)-2-benzyl-3-[(2S)-2-(3-fluoro-4-methanesulfona...)
Affinity DataKi:  43nM ΔG°:  -43.7kJ/mole EC50:  8.56nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20312((2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2R)-2-(3-f...)
Affinity DataKi:  53nM ΔG°:  -43.2kJ/mole EC50:  30.3nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20293(2-[(3,4-dimethylphenyl)methyl]-3-({[(3-fluoro-4-me...)
Affinity DataKi:  54nM ΔG°:  -43.2kJ/mole EC50:  7.80nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20289(2-[(4-tert-butylphenyl)methyl]-3-[2-(4-methanesulf...)
Affinity DataKi:  55nM ΔG°:  -43.1kJ/mole EC50:  52nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20309((2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2R)-2-(3-f...)
Affinity DataKi:  64nM ΔG°:  -42.7kJ/mole EC50:  142nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20298(2-[(3,4-dimethylphenyl)methyl]-3-[2-(4-methanesulf...)
Affinity DataKi:  71nM ΔG°:  -42.4kJ/mole EC50:  13.6nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20288(2-[(4-tert-butylphenyl)methyl]-3-[1-(3-fluoro-4-me...)
Affinity DataKi:  74nM ΔG°:  -42.3kJ/mole EC50:  440nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20295(2-[(3,4-dimethylphenyl)methyl]-3-[2-(4-methanesulf...)
Affinity DataKi:  119nM ΔG°:  -41.1kJ/mole EC50:  38nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20301(2-[(3,4-dimethylphenyl)methyl]-3-[2-(4-methanesulf...)
Affinity DataKi:  153nM ΔG°:  -40.5kJ/mole EC50:  133nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20294(2-[(3,4-dimethylphenyl)methyl]-3-[1-(3-fluoro-4-me...)
Affinity DataKi:  157nM ΔG°:  -40.4kJ/mole EC50:  151nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20304(2-[(3,4-dimethylphenyl)methyl]-3-{[1-(4-methanesul...)
Affinity DataKi:  239nM ΔG°:  -39.3kJ/mole EC50:  118nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20300(2-[(3,4-dimethylphenyl)methyl]-3-[2-(3-fluoro-4-me...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/mole EC50:  65nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20307((2R)-2-benzyl-3-[(2R)-2-(3-fluoro-4-methanesulfona...)
Affinity DataKi:  298nM ΔG°:  -38.7kJ/mole EC50:  98nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20305((2S)-2-benzyl-3-[(2R)-2-(3-fluoro-4-methanesulfona...)
Affinity DataKi:  370nM ΔG°:  -38.2kJ/mole EC50:  205nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20299(2-[(3,4-dimethylphenyl)methyl]-3-[2-(4-methanesulf...)
Affinity DataKi:  370nM ΔG°:  -38.2kJ/mole EC50:  104nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20302(2-[(3,4-dimethylphenyl)methyl]-3-{[1-(4-methanesul...)
Affinity DataKi:  396nM ΔG°:  -38.0kJ/mole EC50:  197nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM20284(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Affinity DataKi:  1.30E+3nM ΔG°:  -34.9kJ/mole EC50:  520nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

LigandPNGBDBM20303(2-[(3,4-dimethylphenyl)methyl]-3-{[1-(3-fluoro-4-m...)
Affinity DataKi:  1.58E+3nM ΔG°:  -34.4kJ/mole EC50:  567nMpH: 7.4 T: 37°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed