Compile Data Set for Download or QSAR
maximum 50k data
Found 34 Enz. Inhib. hit(s) with all data for entry = 50022100
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231610((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(4-(4...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231615((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopr...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CCR2 receptor in human monocytes assessed as inhibition of MCP1-mediated chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231619((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-(2-hy...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at CCR2 receptor in human monocytes assessed as inhibition of MCP1-mediated chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231620((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(4-(4...)
Affinity DataIC50:  3nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231613(CHEMBL258246 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231615((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopr...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231615((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopr...)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231614(CHEMBL403033 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231611(CHEMBL255312 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231612(CHEMBL255513 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231619((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-(2-hy...)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231620((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(4-(4...)
Affinity DataIC50:  16nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231618(CHEMBL401608 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  24nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231617(3-(1-((1R,3S)-3-((3,5-bis(trifluoromethyl)benzyl)c...)
Affinity DataIC50:  41nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231617(3-(1-((1R,3S)-3-((3,5-bis(trifluoromethyl)benzyl)c...)
Affinity DataIC50:  41nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231621(CHEMBL256954 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  44nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231608(3-(1-(3-((3,5-bis(trifluoromethyl)benzyl)carbamoyl...)
Affinity DataIC50:  45nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231613(CHEMBL258246 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  45nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231622(CHEMBL257160 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  50nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231610((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-3-(4-(4...)
Affinity DataIC50:  54nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231616(CHEMBL401609 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  64nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231611(CHEMBL255312 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  67nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231621(CHEMBL256954 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  130nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231609(CHEMBL402010 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  144nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231623(CHEMBL257159 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  165nMAssay Description:Displacement of [125I]MCP1 from CCR2 receptor in human monocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231618(CHEMBL401608 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  186nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231614(CHEMBL403033 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  217nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231612(CHEMBL255513 | N-(3,5-bis(trifluoromethyl)benzyl)-...)
Affinity DataIC50:  224nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231617(3-(1-((1R,3S)-3-((3,5-bis(trifluoromethyl)benzyl)c...)
Affinity DataIC50:  600nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231617(3-(1-((1R,3S)-3-((3,5-bis(trifluoromethyl)benzyl)c...)
Affinity DataIC50:  600nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231619((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-(2-hy...)
Affinity DataIC50:  844nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231615((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopr...)
Affinity DataIC50:  1.80E+3nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231615((1S,3R)-N-(3,5-bis(trifluoromethyl)benzyl)-1-isopr...)
Affinity DataIC50:  1.80E+3nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50231608(3-(1-(3-((3,5-bis(trifluoromethyl)benzyl)carbamoyl...)
Affinity DataIC50:  1.97E+4nMAssay Description:Displacement of [33S]MK499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed