Compile Data Set for Download or QSAR
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Report error Found 93 Enz. Inhib. hit(s) with all data for entry = 2473
LigandPNGBDBM21034((1R,3R,5S,6S,18S)-6-hydroxy-18-(methoxymethyl)-1,5...)
Affinity DataIC50:  2.70nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21042((2R,3S,6E,14S,15S,17R)-6-({[2-(dimethylamino)ethyl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21036((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Affinity DataIC50:  6.40nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21036((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Affinity DataIC50:  8nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21041((2R,3S,6E,14S,15S,17R)-6-({[2-(dimethylamino)ethyl...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21039((2R,3S,6Z,14S,15S,17R)-6-({tert-butyl[2-(dimethyla...)
Affinity DataIC50:  9.60nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21047((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21036((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Affinity DataIC50:  11nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21043((2R,3S,6E,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21036((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Affinity DataIC50:  13nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21049((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21046((2R,3S,6E,14S,15S,17R)-6-({bis[3-(dimethylamino)pr...)
Affinity DataIC50:  22nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21048((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21045((2R,3S,6E,14S,15S,17R)-6-({[2-(diethylamino)ethyl]...)
Affinity DataIC50:  24nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21065(17-Hydroxywortmannin, S25 | methyl 1-{[(2R,3S,6E,1...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21066(1-{[(2R,3S,6E,14S,15S,17R)-17-(acetyloxy)-8,14-dih...)
Affinity DataIC50:  33nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21068((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  37nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21061((2R,3S,6E,14S,15S,17R)-6-({4-[3-(dimethylamino)pro...)
Affinity DataIC50:  38nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21057((2R,3S,6E,14S,15S,17R)-6-[(4-cyclohexylpiperazin-1...)
Affinity DataIC50:  43nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21063((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  45nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21044((2R,3S,6E,14S,15S,17R)-6-({[2-(diethylamino)ethyl]...)
Affinity DataIC50:  50nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21059((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  56nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21069((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  60nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21067((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  63nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21040((2R,3S,6Z,14S,15S,17R)-6-({benzyl[2-(dimethylamino...)
Affinity DataIC50:  66nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21062((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  78nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21058((2R,3S,6E,14S,15S,17R)-6-[(4-benzylpiperazin-1-yl)...)
Affinity DataIC50:  87nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21035((2R,3S,6E,15S,17R)-6-{[bis(prop-2-en-1-yl)amino]me...)
Affinity DataIC50:  88nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21060((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  90nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21056((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  91nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21070((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  104nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21050((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  127nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21064((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  172nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21052(17-Hydroxywortmannin, S12 | 4-({[(2R,3S,6E,14S,15S...)
Affinity DataIC50:  193nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21034((1R,3R,5S,6S,18S)-6-hydroxy-18-(methoxymethyl)-1,5...)
Affinity DataIC50:  193nMpH: 7.4 T: 30°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21054((2R,3S,6E,14S,15S,17R)-6-{[(2,3-dihydroxypropyl)(m...)
Affinity DataIC50:  199nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21061((2R,3S,6E,14S,15S,17R)-6-({4-[3-(dimethylamino)pro...)
Affinity DataIC50:  249nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21026((2R,3S,6Z,14S,15S,17R)-6-[(diethylamino)methyliden...)
Affinity DataIC50:  382nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21030((2R,3S,6Z,14S,15S,17R)-6-{[tert-butyl(methyl)amino...)
Affinity DataIC50:  440nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21055((2R,3S,6E,14S,15S,17R)-6-{[benzyl(2-cyanoethyl)ami...)
Affinity DataIC50:  444nMAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21033((2R,3S,6Z,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  496nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21067((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  568nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21062((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  619nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21032((2R,3S,6Z,14S,15S,17R)-6-{[butyl(methyl)amino]meth...)
Affinity DataIC50:  635nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM21038((2R,3S,6Z,14S,15S,17R)-6-({[3-(dimethylamino)propy...)
Affinity DataIC50:  638nMpH: 7.5 T: 22°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21059((2R,3S,6E,14S,15S,17R)-8,14-dihydroxy-3-(methoxyme...)
Affinity DataIC50:  692nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21044((2R,3S,6E,14S,15S,17R)-6-({[2-(diethylamino)ethyl]...)
Affinity DataIC50:  767nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21039((2R,3S,6Z,14S,15S,17R)-6-({tert-butyl[2-(dimethyla...)
Affinity DataIC50:  816nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21057((2R,3S,6E,14S,15S,17R)-6-[(4-cyclohexylpiperazin-1...)
Affinity DataIC50:  820nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM21066(1-{[(2R,3S,6E,14S,15S,17R)-17-(acetyloxy)-8,14-dih...)
Affinity DataIC50:  822nMAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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