Compile Data Set for Download or QSAR
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Found 24 Enz. Inhib. hit(s) with all data for entry = 50022465
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235501(CHEMBL254707 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells at a membrane potential of -70 mV by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235499(CHEMBL438869 | tert-butyl (R)-1-((R)-5-benzyl-1-me...)
Affinity DataIC50:  25nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235501(CHEMBL254707 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50216671(CHEMBL247828 | tert-butyl (R)-1-((R)-1-isopropyl-2...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235517(CHEMBL254699 | tert-butyl (R)-3-(2-fluorophenyl)-1...)
Affinity DataIC50:  47nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235512(CHEMBL401343 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235513(CHEMBL399886 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235511(CHEMBL253819 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  73nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235510(CHEMBL254928 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  75nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235498(CHEMBL253877 | tert-butyl (R)-1-((R)-5-(cyclobutyl...)
Affinity DataIC50:  81nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235506(CHEMBL252783 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  96nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235516(CHEMBL400293 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  97nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235502(CHEMBL254079 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  101nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235497(CHEMBL428421 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  102nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235500(CHEMBL399273 | tert-butyl (R)-3-(2,5-bis(trifluoro...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235509(CHEMBL399041 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  131nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235514(CHEMBL254914 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  142nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235508(CHEMBL254698 | tert-butyl (R)-1-((R)-1,5-dimethyl-...)
Affinity DataIC50:  142nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235507(CHEMBL252212 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  149nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235504(CHEMBL253627 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  185nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235505(CHEMBL254078 | tert-butyl (R)-1-((R)-5-(cyclohexyl...)
Affinity DataIC50:  188nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235503(CHEMBL252985 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  196nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235515(CHEMBL254915 | tert-butyl (R)-1-((R)-5-(cyclopropy...)
Affinity DataIC50:  219nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50235496(CHEMBL399589 | tert-butyl (R)-3-(2-fluorophenyl)-1...)
Affinity DataIC50:  409nMAssay Description:Inhibition of human Nav1.7 sodium channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed